I2784
INH2BP
≥98% (HPLC), solid
Synonym(s):
5-Iodo-6-amino-1,2-benzopyrone
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About This Item
Empirical Formula (Hill Notation):
C9H6INO2
CAS Number:
Molecular Weight:
287.05
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
Recommended Products
Assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 31 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
Nc1ccc2OC(=O)C=Cc2c1I
InChI
1S/C9H6INO2/c10-9-5-1-4-8(12)13-7(5)3-2-6(9)11/h1-4H,11H2
InChI key
WWRAFPGUBABZSD-UHFFFAOYSA-N
Biochem/physiol Actions
Inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1); anti-apoptotic.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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France Vaillancourt et al.
Arthritis research & therapy, 10(5), R107-R107 (2008-09-11)
4-Hydroxynonenal (HNE) is one of the most abundant and reactive aldehydes of lipid peroxidation products and exerts various effects on intracellular and extracellular signalling cascades. We have previously shown that HNE at low concentrations could be considered as an important
M Endres et al.
European journal of pharmacology, 351(3), 377-382 (1998-08-28)
Peroxynitrite triggers DNA single-strand breakage, which activates the nuclear enzyme poly(ADP-ribose) synthetase (PARS). Activation of PARS depletes its substrate, NAD+, slowing the rate of glycolysis, electron transport, and ATP formation, resulting in cell necrosis. Here, we demonstrate that inhibition of
J G Mabley et al.
British journal of pharmacology, 133(6), 909-919 (2001-07-17)
Activation of poly(ADP-ribose) synthetase (PARS, also termed polyADP-ribose polymerase or PARP) has been proposed as a major mechanism contributing to beta-cell destruction in type I diabetes. In the present study, we have investigated the role of PARS in mediating the
G S Scott et al.
Journal of neuroimmunology, 117(1-2), 78-86 (2001-06-30)
Peroxynitrite formation has been demonstrated during experimental allergic encephalomyelitis (EAE). Furthermore, peroxynitrite has been identified as an activator of poly(ADP-ribose) synthetase (PARS), an enzyme implicated in neurotoxicity. In the current study, we examined the role of PARS activation in the
P I Bauer et al.
Biochimie, 77(5), 374-377 (1995-01-01)
A non-covalently binding inhibitory ligand of poly(ADP-ribose) polymerase, 5-iodo-6-amino-1,2-benzopyrone, when incubated at 5-600 microM external concentration with an E-ras-transformed tumorigenic cell line or with human prostatic carcinoma cells for 40 to 60 days converts both cancer cells to a non-tumorigenic
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