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33969

Supelco

Indoxacarb

PESTANAL®, analytical standard

Synonym(s):

Methyl 7-chloro-2,5-dihydro-2-[N-(methoxycarbonyl)-4-(trifluoromethoxy)anilinocarbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)carboxylate

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About This Item

Empirical Formula (Hill Notation):
C22H17ClF3N3O7
CAS Number:
144171-61-9
Molecular Weight:
527.83
MDL number:
MFCD03792834
UNSPSC Code:
41116107
PubChem Substance ID:
329754710
NACRES:
NA.24

grade

analytical standard

Quality Level

100

description

mixture of isomers

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

SMILES string

COC(=O)N(C(=O)N1CO[C@]2(Cc3cc(Cl)ccc3C2=N1)C(=O)OC)c4ccc(OC(F)(F)F)cc4

InChI

1S/C22H17ClF3N3O7/c1-33-18(30)21-10-12-9-13(23)3-8-16(12)17(21)27-28(11-35-21)19(31)29(20(32)34-2)14-4-6-15(7-5-14)36-22(24,25)26/h3-9H,10-11H2,1-2H3/t21-/m0/s1

InChI key

VBCVPMMZEGZULK-NRFANRHFSA-N

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General description

Indoxacarb belongs to oxadiazine class of insecticides, showing broad-spectrum activity against Lepidoptera and other pests. Its mode of action involves blocking of voltage-gated sodium channels and binding to neuronal nicotinic acetylcholine receptors.

Application

Indoxacarb may be used as an analytical reference standard for the quantification of the analyte in foodstuffs of plant and animal origin using gas chromatography with electron capture detection (GC-ECD) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H301,H317,H332,H372,H410

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1B - STOT RE 1

Target Organs

Blood,Nervous system,Heart, Heart,Nervous system,Blood system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG7057
BCCC9370
BCCC2135
BCBZ7954
BCBX4043

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Michael W Dryden et al.
Parasites & vectors, 6, 126-126 (2013-05-07)
A study was conducted to evaluate the effect of indoxacarb applied to cats on adult cat fleas, Ctenocephalides felis, flea egg production and adult flea emergence. Sixteen cats were selected for the study and allocated to two treatment groups. Eight
Mao Chen et al.
PloS one, 3(5), e2284-e2284 (2008-06-05)
The ecological safety of transgenic insecticidal plants expressing crystal proteins (Cry toxins) from the bacterium Bacillus thuringiensis (Bt) continues to be debated. Much of the debate has focused on nontarget organisms, especially predators and parasitoids that help control populations of
Determination of indoxacarb residue in foodstuffs of plant and animal origin by GC-ECD and LC-MS/MS.
Dun-Ming Xu, et al.
Agricultural sciences in China, 7(10), 128-1234 (2008)
Methemoglobinemia induced by indoxacarb intoxication.
Wu J-Y, et al.
Clinical Toxicology, 48(7), 766-767 (2010)
Franklin Y Quarcoo et al.
Insects, 10(2) (2019-02-02)
Behavioral symptoms and mortality associated with intoxication with insecticides fipronil and indoxacarb were determined in field-collected eastern subterranean termites, Reticulitermes flavipes (Kollar), and Formosan subterranean termites, Coptotermes formosanus Shiraki. Behaviors and mortality were evaluated at three temperatures (16, 22, and
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