CBL2117
Anti-Interleukin-6 Antibody, clone B-E8
clone B-E8, Chemicon®, from mouse
Synonym(s):
IL-6, B-cell stimulatory factor 2, Interferon beta-2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
100
300
antibody form
purified antibody
antibody product type
primary antibodies
clone
B-E8, monoclonal
species reactivity
human
should not react with
mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable
neutralization: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... IL6(3569)
Related Categories
Specificity
Recognizes natural and recombinant forms of human Interleukin-6 with an affinity of 0.5 nM. Inhibits IL-6 binding to its receptors and blocks Interleukin-6 induced proliferation on B9 cells.
Immunogen
Recombinant human IL-6.
Application
Blocks Interleukin-6 induced proliferation on B9 cells: 20pg of antibody neutralizes the activity of 1U of IL-6. It is recommended that the sodium azide is removed from the antibody prior to use in this application.
Immunohistochemistry on frozen sections
Optimal working dilutions must be determined by the end user.
Immunohistochemistry on frozen sections
Optimal working dilutions must be determined by the end user.
Detect Interleukin-6 using this Anti-Interleukin-6 Antibody, clone B-E8 validated for use in ELISA, FC, IH, NEUT.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
Cytokines & Cytokine Receptors
Linkage
Replaces: 04-1095
Physical form
Format: Purified
The monoclonal is purified from tissue culture supernatant by ion exchange chromatography and is presented as a liquid in phosphate buffered saline, pH 7.2.
Storage and Stability
Store at 2-8°C for up to 12 months from date of receipt. For long term storage aliquot antibody into small volumes and store at -20°C. Avoid repeated freeze-thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions.
Balini Balasubramaniam,Debra A Carter,Eric J Mayer,Andrew D Dick
Experimental Eye Research null
Elevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary disease.
A M W Petersen,M Penkowa,M Iversen,L Frydelund-Larsen,J L Andersen,J Mortensen,P Lange,B K Pedersen
Lung null
Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise.
Penkowa, M; Keller, C; Keller, P; Jauffred, S; Pedersen, BK
Faseb Journal null
Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes.
Tianjiong Lou,Zhongai Zhang,Zhilei Xi,Kang Liu,Lin Li,Baolin Liu,Fang Huang
Inflammation null
S Zanotti et al.
Osteoarthritis and cartilage, 21(11), 1766-1773 (2013-08-21)
Notch receptors determine cell fate by regulating transcription, an event mediated by the Notch intracellular domain (NICD), which is generated by proteolysis brought about by Notch-ligand interactions. Since Notch activation or exposure to interleukin (Il)6 have similar effects in chondrocytes
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