ABN410
Anti-ZNF423 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, hOAZ, Smad- and Olf-interacting zinc finger protein, ZFP423
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All Photos(4)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, human, mouse
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ZNF423(23090)
General description
ZNF423, also known as Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, hOAZ, or Smad and Olf-interacting zinc finger protein, and encoded by the gene ZNF423/KIAA0760/NPHP14/OAZ, is a transcription factor that can both act as an activator or a repressor depending on the context. ZNF423 plays a central role in BMP signaling and olfactory neurogenesis. ZNF423 acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation. ZNF423 is involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons and it controls the proliferation and differentiation of neural precursors in cerebellar vermis formation. ZNF423 is expressed in many organs including the brain, lung, skeletal muscle and heart in both fetal and adult states. Defects in ZNF423 cause the genetic kidney disease nephronophthisis and the neurological disorder called Joubert syndrome.
Immunogen
Epitope: Near C-terminus
KLH-conjugated linear peptide corresponding to a region near the C-terminus of human ZNF423. (Note: The immunogen contains 93% sequence homology with bovine.)
Application
Anti-ZNF423 Antibody is an antibody against ZNF423 for use in western blotting, IHC (Paraffin) & ICC.
Immunohistochemistry Analysis: A 1:500 and a 1:50 dilution from a representative lot detected ZNF423 in human and rat cerebellum tissues, respectively.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected ZNF423 in human thalamus and hippocampus tissues.
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected ZNF423 in NIH/3T3 cells.
DyLight® is a registered trademark of Thermo Fisher Scientific.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected ZNF423 in human thalamus and hippocampus tissues.
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected ZNF423 in NIH/3T3 cells.
DyLight® is a registered trademark of Thermo Fisher Scientific.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
Quality
Evaluated by Western Blotting in mouse P7 brain tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected ZNF423 in 10 µg of mouse P7 brain tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected ZNF423 in 10 µg of mouse P7 brain tissue lysate.
Target description
~125 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
DyLight is a registered trademark of Pierce Biotechnology, Inc.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Gen Wang et al.
Breast cancer research and treatment, 175(3), 567-578 (2019-04-03)
In early stage, ERα-positive breast cancer, concurrent use of endocrine therapy and chemotherapy has not been shown to be superior to sequential use. We hypothesized that genetic biomarkers can aid in selecting patients who would benefit from chemo-endocrine therapy. Our
William N Addison et al.
Molecular and cellular biology, 39(8) (2019-01-30)
Satellite cells (SCs) are skeletal muscle stem cells that proliferate in response to injury and provide myogenic precursors for growth and repair. Zfp423 is a transcriptional cofactor expressed in multiple immature cell populations, such as neuronal precursors, mesenchymal stem cells
Thanh N Dang et al.
BMC cancer, 22(1), 300-300 (2022-03-23)
Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dedifferentiated liposarcoma (DDLPS) is highly aggressive and has an overall 5-year survival rate of 30% as compared
Ojas Deshpande et al.
PLoS genetics, 16(9), e1009017-e1009017 (2020-09-15)
Interpreting rare variants remains a challenge in personal genomics, especially for disorders with several causal genes and for genes that cause multiple disorders. ZNF423 encodes a transcriptional regulatory protein that intersects several developmental pathways. ZNF423 has been implicated in rare
Chen-Cheng Lee et al.
Molecular cell, 76(3), 500-515 (2019-08-20)
Diet-induced obesity can be caused by impaired thermogenesis of beige adipocytes, the brown-like adipocytes in white adipose tissue (WAT). Promoting brown-like features in WAT has been an attractive therapeutic approach for obesity. However, the mechanism underlying beige adipocyte formation is
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