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M1381

Sigma-Aldrich

4-Methylumbelliferone

≥98%

Synonym(s):

β-Methylumbelliferone, 4-MU, 7-Hydroxy-4-methylcoumarin

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About This Item

Empirical Formula (Hill Notation):
C10H8O3
CAS Number:
90-33-5
Molecular Weight:
176.17
Beilstein:
142217
EC Number:
201-986-7
MDL number:
MFCD00006866
UNSPSC Code:
12352100
PubChem Substance ID:
57654353
NACRES:
NA.22

Assay

≥98%

color

off-white to yellow

fluorescence

λex 372 nm; λem 445 nm in ethanol

SMILES string

CC1=CC(=O)Oc2cc(O)ccc12

InChI

1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3

InChI key

HSHNITRMYYLLCV-UHFFFAOYSA-N

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Application

4-Methylumbelliferone is primarily used in synthesizing medicinal compounds and as a building block for fluorescent probes. Applications include synthesis of:
  • coumarin triazole derivatives as potential antimicrobial agents.
  • coumarin salen-based fluorescence sensors for Mg2+ detection.
  • pyranocoumarin derivatives as anti-hyperglycemic and anti-dyslipidemic agents.
  • coumarin piperazine derivatives as potential multireceptor atypical antipsychotics.
  • 4-methylumbelliferyl T-antigen as a substrate for endo-α-N-acetylgalactosaminidase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents.
Shi Y and Zhou C-H
Bioorganic & Medicinal Chemistry Letters, 21(3), 956-960 (2011)
Pyranocoumarins: A new class of anti-hyperglycemic and anti-dyslipidemic agents.
Kumar A, et al.
Bioorganic & Medicinal Chemistry Letters, 19(22), 6447-6451 (2009)
Yiyi Liu et al.
ACS nano, 13(6), 6760-6769 (2019-05-31)
Thiol-polystyrene (SH-PS)-capped plasmonic nanoparticles can be fabricated into free-standing, one-nanoparticle-thick superlattice sheets (termed plasmene) based on physical entanglement between ligands, which, however, suffer from irreversible dissociation in organic solvents. To address this issue, we introduce coumarin-based photo-cross-linkable moieties to the
Na+ triggered fluorescence sensors for Mg2+ detection based on a coumarin salen moiety.
Dong Y, et al.
Organic Letters, 13(9), 2252-2255 (2011)
Tz-Ching Yeh et al.
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