592293

2-Methoxyethyl chloroformate

• Synonym(s): (2-Methoxyethoxy)carbonyl chloride, (Chloro)(2-methoxyethoxy)methanone, 2-Methoxyethyl carbonochloridate, Chloroformic acid 2-methoxyethyl ester
• Linear Formula: CH₃OCH₂CH₂OCOCl
• CAS Number: 628-12-6
• Molecular Weight: 138.55
• EC Number: 211-026-9
• MDL number: MFCD00058932
• UNSPSC Code: 12352100
• PubChem Substance ID: 24881382

Properties

• refractive index: n20/D 1.4200 (lit.)
• bp: 157-158 °C (lit.)
• density: 1.192 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: COCCOC(Cl)=O
• InChI: 1S/C4H7ClO3/c1-7-2-3-8-4(5)6/h2-3H2,1H3
• InChI key: NDYYWMXJZWHRLZ-UHFFFAOYSA-N

Description

Application

Reactant for:

• Preparation of N-bridged bicyclic sulfonamides as inhibitors of γ-secretase
• Preparation of dimethoxyethyl azodicarboxylate via amidation/oxidation and application to Mitsunobu reaction
• Regioselective, stereoselective, and kinetically-controlled nickel-catalyzed cyanoesterification of allenes chloroformates and TMSCN
• Preparation of amino carboxamidobenzothiazoles as Lck inhibitors
• Preparation of nonracemic spirooxindoles using a stereoselective three-component coupling reaction as the key step and using acylation reactions to add structural diversity

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H226,H314
• Precautionary Statements: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 138.0 °F - closed cup
• Flash Point(C): 58.9 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves