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371858

Sigma-Aldrich

6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole hydrochloride

97%

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O · HCl
CAS Number:
35764-54-6
Molecular Weight:
238.71
MDL number:
MFCD00075570
UNSPSC Code:
12171500
PubChem Substance ID:
24863132

Assay

97%

mp

288-290 °C (lit.)

SMILES string

Cl[H].COc1ccc2[nH]c3CNCCc3c2c1

InChI

1S/C12H14N2O.ClH/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11;/h2-3,6,13-14H,4-5,7H2,1H3;1H

InChI key

KRMJEIDSHZEQHJ-UHFFFAOYSA-N

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
03704LX

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J O Marcusson et al.
Molecular pharmacology, 30(2), 121-128 (1986-08-01)
Recently, a high affinity [3H]imipramine-binding site of protein nature that appeared to be related to the 5-hydroxytryptamine (5-HT, serotonin) uptake mechanism was demonstrated. This binding site was only part of desipramine-displaceable [3H]imipramine binding, which contained a significant amount of additional
R Pähkla et al.
Pharmacological research, 34(1-2), 73-78 (1996-07-01)
Pinoline (6-methoxy-1,2,3,4-tetrahydro-beta-carboline) is a naturally occurring compound in the mammalian body which inhibits serotonin (5-hydroxytryptamine) uptake and monoamine oxidase-A activity. The present study was designed to assess potential antidepressant- or anxiolytic-like behavioural effects of pinoline in rat forced swimming, open
M Aranda et al.
Journal of pineal research, 49(1), 78-85 (2010-06-08)
The protective in vivo effects of melatonin or pinoline on carbon tetrachloride (CCl(4))-induced oxidative damage were investigated in liver of rats and compared to rats injected only with CCl(4) (5 mL/kg body weight). Hepatic cell membrane fluidity, monitored using fluorescence
Sergio Millán-Plano et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 17(1), 39-44 (2003-05-21)
The serum concentrations of aluminum, a metal potentially involved in the pathogenesis of Alzheimer's disease, increase with age. Also, intense and prolonged exposure to aluminum may result in dementia. Melatonin and pinoline are two well known antioxidants that efficiently reduce
D L Taylor et al.
Research communications in chemical pathology and pharmacology, 47(1), 133-136 (1985-01-01)
6-MeOTHBC binds to both high and low affinity receptors in human platelets. The beta-carboline is less active than chlorimipramine at the low affinity site, and it is weaker than methysergide, a known 5-HT antagonist, at the high affinity site. The
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