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About This Item
Linear Formula:
CH3(CH2)4C≡CCO2H
CAS Number:
Molecular Weight:
140.18
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Recommended Products
Assay
98%
refractive index
n20/D 1.46 (lit.)
bp
148-149 °C/19 mmHg (lit.)
mp
2-5 °C (lit.)
density
0.961 g/mL at 25 °C (lit.)
SMILES string
CCCCCC#CC(O)=O
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Flash Point(F)
213.8 °F - closed cup
Flash Point(C)
101 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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J M Fletcher et al.
Metabolism: clinical and experimental, 48(6), 685-688 (1999-06-25)
2-Octynoic acid was administered by intraperitoneal injection to fasted Sprague-Dawley rats in an attempt to simulate medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency. The resultant urine organic acid profile showed a mild dicarboxylic aciduria but lacked the glycine conjugates characteristic of
Phornnop Naiyanetr et al.
Journal of autoimmunity, 37(3), 209-216 (2011-07-19)
Our laboratory has hypothesized that xenobiotic modification of the native lipoyl moiety of the major mitochondrial autoantigen, the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), may lead to loss of self-tolerance in primary biliary cirrhosis (PBC). This thesis is
Si-Jie Wu et al.
Hepatology (Baltimore, Md.), 53(3), 915-925 (2011-03-05)
Murine models of autoimmunity allow the study of the earliest events in disease pathogenesis. Our laboratory has developed a xenobiotic induced model of primary biliary cirrhosis (PBC) following immunization of mice with 2-octynoic acid coupled to bovine serum albumin (2-OA-BSA)
J A Montgomery et al.
Biomedical & environmental mass spectrometry, 18(6), 416-423 (1989-06-01)
Rats given 2-octynoic acid by intraperitoneal injection excrete elevated amounts of medium-chain dicarboxylic acids and other acidic metabolites usually associated with human medium-chain acyl-CoA dehydrogenase deficiency. Onset of this organic acid profile is immediate and lasts for approximately 24 h.
Amy Dhirapong et al.
Hepatology (Baltimore, Md.), 57(2), 708-715 (2012-09-22)
Collectively, the data in both humans and murine models of human primary biliary cirrhosis (PBC) suggest that activated T cells, particularly CD8 T cells, play a critical role in biliary cell destruction. Under physiological conditions, T-cell activation involves two critical
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