Skip to Content
Merck
All Photos(1)

Documents

SRP0439

Sigma-Aldrich

PrCP active human

recombinant, expressed in FreeStyle 293-F cells, ≥15% (SDS-PAGE)

Synonym(s):

HUMPCP, PCP, prolylcarboxypeptidase

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in FreeStyle 293-F cells

Assay

≥15% (SDS-PAGE)

form

aqueous solution

mol wt

53 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

0.06 mg/mL

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PRCP(5547)

General description

Human recombinant Lysosomal Pro-X carboxypeptidase, also known as angiotensinase C (GenBank Accession No. NM_005040) amino acids 31-496 with C-terminal His-tag, MW=53 kDa, expressed in HEK293 cells.

Application

Useful for the cleavage of C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin.

Legal Information

FreeStyle is a trademark of Invitrogen Corp.

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Lin Wang et al.
American journal of obstetrics and gynecology, 195(1), 162-171 (2006-05-10)
Renin-angiotensin System is essential for the homeostasis of blood pressure in humans. The roles of renin-angiotensin system gene polymorphisms including angiotensinogen, angiotensin-converting enzyme, renin and angiotensin II receptor, type 1 genes in the pathogenesis of preeclampsia have been extensively studied
New enzymatic route for the inactivation of angiotensin.
H Y Yang et al.
Nature, 218(5148), 1224-1226 (1968-06-29)
F Tan et al.
The Journal of biological chemistry, 268(22), 16631-16638 (1993-08-05)
Prolylcarboxypeptidase, a lysosomal serine carboxypeptidase, cleaves COOH-terminal amino acids linked to proline, as in angiotensin II and III and [des-Arg9] bradykinin. About 25% of the enzyme protein was sequenced, and the complete sequence was deduced from its human kidney cDNA.
Ok Jeong Moon et al.
Advanced healthcare materials, 11(15), e2200765-e2200765 (2022-06-08)
Cancer chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine, which are mostly small synthetic molecules, are still clinically useful for cancer treatment. However, despite considerable therapeutic efficacy, severe toxicity-associated problems, which are mainly caused by the non-specific mode of

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service