SML0884

bpV(HOpic)

≥90% V basis

• Synonym(s): Bisperoxovanadium(HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V), K₂[VO(O₂)2C₆H₄NO₃]
• Empirical Formula (Hill Notation): K₂VOO₂O₂C₆H₄NO₃
• CAS Number: 722494-26-0
• Molecular Weight: 347.24
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥90% V basis
• form: powder
• storage condition: desiccated; protect from light
• color: faintly yellow to dark yellow
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [V]32(OO3)(OO2)([NH]1=CC(=O)CC=C1C(=O)[O-])[O-].[K+].[K+].O.O.O.O
• InChI: 1S/C6H5NO3.2K.2O2.4H2O.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;;;;;/h2-3H,1H2,(H,9,10);;;;;4*1H2;;/q;2*+1;2*-2;;;;;-1;+4/p-1
• InChI key: HSCJTESZNNRNPK-UHFFFAOYSA-M

Description

Application

bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.[1]

Biochem/physiol Actions

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.

Other Notes

Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable