AIF1 (allograft inflammatory factor 1) is a calcium-binding, cytoplasmic protein that has 143-amino acids. It is also known as IBA1 (ionized calcium-binding adapter molecule 1). It is expressed in the cells of the monocyte/macrophage lineage, as well as in microglial and dendritic cells. It is located on human chromosome 6p21.3.
Immunogen
Peptide with sequence C-NKQFLDDPKYSSDED from the internal region of the protein sequence according to NP_001614.3.
Application
Anti-AIF1/IBA1 (Isoform 3) antibody produced in goat has been used in western blotting and immunofluorescence.
Biochem/physiol Actions
AIF1 (allograft inflammatory factor 1) is an essential factor of macrophage chemotaxis. Expression of AIF1 regulates the proliferation of vascular smooth muscle cells by G-CSF (cytokine granulocyte-colony stimulating factor) autocrine expression.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Inhibition of AIF-1 expression by constitutive siRNA expression reduces
macrophage migration, proliferation, and signal transduction initiated by
atherogenic stimuli.
Ying T, et al.
American Journal of Physiology. Cell Physiology (2005)
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Wang Q, et al.
Cancer Cell, 32(1), 42-56 (2017)
Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation.
Frontiers in aging neuroscience, 16, 1393351-1393351 (2024-06-05)
Iron dyshomeostasis and neuroinflammation, characteristic features of the aged brain, and exacerbated in neurodegenerative disease, may induce oxidative stress-mediated neurodegeneration. In this study, the effects of potential priming with mild systemic iron injections on subsequent lipopolysaccharide (LPS)-induced inflammation in adult
dolescent binge alcohol exposure affects the brain function through mitochondrial impairment
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