PD-1 (programmed death-1) is an immunosuppressive molecule, which is also known as PDCD1 (programmed cell death 1). It is located on chromosome 2q37.3. It is a member of immunoglobulin receptor superfamily.
Immunogen
a 16 amino acid peptide from near the carboxy-terminus of human PD-1.
Biochem/physiol Actions
PD-1 (programmed death-1) gene is sensitive to systemic lupus erythematosus (SLE). Polymorphisms in PD-1 may participate in the growth of EOC (epithelial ovarian cancer). It acts as a negative regulator of T cells. It is also responsible for immune escape mediated by tumor cell.
Linkage
The action of this antibody can be blocked using blocking peptide SBP4065.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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