I7016

H-7 dihydrochloride

≥98% (HPLC)

• Synonym(s): 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride, Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
• Empirical Formula (Hill Notation): C₁₄H₁₇N₃O₂S · 2HCl
• CAS Number: 108930-17-2
• Molecular Weight: 364.29
• Beilstein: 5840763
• MDL number: MFCD00036961
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278496
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• solubility: H₂O: 20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23
• InChI: 1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
• InChI key: OARGPFMFRLLKPF-UHFFFAOYSA-N
• Gene Information: human ... PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584)

Description

General description

H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).

Application

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Biochem/physiol Actions

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

Caution

Light sensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves