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E8250

Sigma-Aldrich

Esculin hydrate

≥98%

Synonym(s):

(-)-Esculin, 6,7-Dihydroxycoumarin 6-glucoside, Esculetin 6-β-D-glucoside

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About This Item

Empirical Formula (Hill Notation):
C15H16O9 · xH2O
CAS Number:
531-75-9
Molecular Weight:
340.28 (anhydrous basis)
EC Number:
208-517-5
MDL number:
MFCD00149492
UNSPSC Code:
12352201
PubChem Substance ID:
24894668
NACRES:
NA.25

Assay

≥98%

SMILES string

O.OC[C@H]1O[C@@H](Oc2cc3C=CC(=O)Oc3cc2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C15H16O9.H2O/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17;/h1-4,10,12-17,19-21H,5H2;1H2/t10-,12-,13+,14-,15-;/m1./s1

InChI key

CQYPGSKIFJFVDQ-QWFKVUSTSA-N

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General description

Esculin hydrate has vasoprotective and venotonic properties.

Application

Esculin hydrate has been used as a component of sporulation-inducing esculin agar. It has also been used for esculin uptake assay.

Biochem/physiol Actions

Esculin is a coumarin glycoside that demonstrates antioxidant activitites and protection against chemically-induced carcinogenesis. Esculin is utilized in microbiology for the isolation and identification of Enterococcus (group D streptococci).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Safety Properties and probiotic potential of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895
Ma QJ, et al.
Sci. Hortic., 220, 259-266 (2017)
The Clinician's Handbook of Natural Medicine (2015)
S G Jenkins et al.
Journal of clinical microbiology, 49(11), 3947-3949 (2011-09-02)
A total of 142 stool specimens were evaluated for vancomycin-resistant enterococcus (VRE). Twenty-four-hour sensitivities and specificities, respectively, were 98% and 95% for Spectra VRE chromogenic agar (Remel, Lenexa, KS), 86% and 92% for bile esculin azide with vancomycin (BEAV; Remel)
Maria Grazia Sarpietro et al.
Journal of natural products, 74(4), 790-795 (2011-03-23)
Three coumarins, scopoletin (1), esculetin (2), and esculin (3), were investigated by differential scanning calorimetry and Langmuir-Blodgett techniques to gain information about the interaction of these compounds with cellular membranes. Phospholipids assembled as multilamellar vesicles or monolayers (at the air-water
Yifan Hu et al.
Journal of agricultural and food chemistry, 57(9), 3845-3852 (2009-05-07)
The enzymatic esterification of esculin catalyzed by Candida antarctica lipase B (Novozym 435) was carried out in ionic liquid (IL)-organic solvent mixed systems in comparison with individual systems. The reaction behaviors in IL-organic solvents were systemically evaluated using acetone as
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