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D8428

Sigma-Aldrich

Decorin from bovine articular cartilage

salt-free, lyophilized powder

Synonym(s):

Decorin protein

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About This Item

MDL number:
MFCD00283027
UNSPSC Code:
12352202
NACRES:
NA.75

biological source

bovine articular cartilage

Quality Level

200

form

salt-free, lyophilized powder

mol wt

~100 kDa

packaging

glass bottle of 0.5 mg

technique(s)

cell culture | mammalian: suitable

solubility

PBS: ≥2.00 mg/mL, clear, colorless to yellow

UniProt accession no.

P21793

storage temp.

−20°C

Gene Information

cow ... DCN(280760)

General description

Decoran is a small proteoglycan composed of a chondroitin/dermatan sulfate glycosaminoglycans attached to a 40 kDa core protein. It is found primarily in the extracellular matrix of articular cartilage. Decorin interacts with collagen types I and II via its core protein wherein it delays fibrillogenesis. Decorin also interacts with fibronectin, thrombospondin and TGF-β isoforms, and the EGF-receptor.
Decorin from bovine articular cartilage is a proteoglycan that belongs to the small leucine-rich repeat proteoglycans and proteins (SLRPs) family. Decorin is present in almost all tissues. It has a protein core composed of leucine-rich repeats (LRRs), flanked by two cysteine-rich regions.

Application

Decorin from bovine articular cartilage has been used in solid phase binding assay (ELISA), binding assays, binding inhibition assay, parasite binding assays, scaffold fabrication, quartz crystal microbalance assay, inhibition of CSA (chondroitin sulphate A) binding assay and glycans and glycan biotinylation.

Biochem/physiol Actions

Decorin plays an important role in guiding the proper assembly of collagen during fibrillogenesis. Deficiency in decorin results in altered tissue structure and function. It controls growth factors like EGF and TGF-β. Decorin blocks aggregation of fibrils into fibers and fibrillogenesis in cell-free constructs of polymerized type I collagen.

Other Notes

Decorin is an approx. 100 kDa proteoglycan consisting of a 40 kDa core protein and one chondroitin or dermatan sulfate glycosaminoglycan chain. From 0.2 μm filtered solution prior to lyophilization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Seda Duran G Ler et al.
Indian journal of ophthalmology, 69(2), 369-373 (2021-01-20)
The aims of this study were to evaluate the effects of decorin (DCN) in rat oxygen-induced retinopathy (OIR) model and to compare the results with those of bevacizumab. Twenty-eight newborn Sprague-Dawley rats were randomly divided into four groups. Group I
Caroline Pehrson et al.
Vaccine, 35(4), 610-618 (2016-12-26)
Malaria in pregnancy is associated with significant morbidity in pregnant women and their offspring. Plasmodium falciparum infected erythrocytes (IE) express VAR2CSA that mediates binding to chondroitin sulphate A (CSA) in the placenta. Two VAR2CSA-based vaccines for placental malaria are in
Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels.
Reese S P, et al.
Matrix Biology, 32(7-8), 414-423 (2013)
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
Clausen T M, et al.
The Journal of Biological Chemistry, 287(28), 23332-23345 (2012)
Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies.
Khunrae P, et al.
Journal of Molecular Biology, 397(3), 826-834 (2010)
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