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SYNPLE-P082

Sigma-Aldrich

Reagent-cartridge VHL-COOH-PEG2

Synple

Synonym(s):

Synple 2

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100 μG
¥72,100

¥72,100


Availability

Estimated to ship onFebruary 21, 2025


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100 μG
¥72,100

About This Item

MDL number:
UNSPSC Code:
12352401
NACRES:
NA.22

¥72,100


Availability

Estimated to ship onFebruary 21, 2025


To order products, please contact your local dealer.

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antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

General description

Reagent-cartridge VHL-COOH-PEG2 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected amine to the carboxylic acid terminated linker through an amide coupling. This cartridge features a von Hippel-Lindau (VHL) recruiting ligand ((S,R,S)-AHPC) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol

Linker: PEG2

E3 ligase target and ligand: von Hippel-Lindau (VHL), (S,R,S)-AHPC

Terminal functional group: carboxylic acid

Compatible substrates: amine

Cartridge contents:


  • Supported carbodiimide and Oxyma Pure (coupling reagents)
  • Supported carbonate (acid scavenger)
  • SCX2 (for purification)
  • Degrader building block linker reagent
Related Cartridges:
  • SYNPLE-P001 Reagent-cartridge CRBN-PEG1
  • SYNPLE-P002 Reagent-cartridge CRBN-PEG2
  • SYNPLE-P003 Reagent-cartridge CRBN-PEG3
  • SYNPLE-P004 Reagent-cartridge CRBN-PEG4
  • SYNPLE-P005 Reagent-cartridge CRBN-PEG5
  • SYNPLE-P022 Reagent-cartridge VHL-PEG2
  • SYNPLE-P023 Reagent-cartridge VHL-PEG3
  • SYNPLE-P024 Reagent-cartridge VHL-PEG4
  • SYNPLE-P025 Reagent-cartridge VHL-PEG5
  • SYNPLE-P072 Reagent-cartridge CRBN-COOH-PEG2
  • SYNPLE-P073 Reagent-cartridge CRBN-COOH-PEG3
  • SYNPLE-P074 Reagent-cartridge CRBN-COOH-PEG4
  • SYNPLE-P083 Reagent-cartridge VHL-COOH-PEG3
  • SYNPLE-P084 Reagent-cartridge VHL-COOH-PEG4
Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks.

Features and Benefits of Synple Platform
  • Time savings – pre-installed protocols have been highly optimized, which obviates the need for the user’s own reaction development and optimization
  • Easy to use – protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
  • Safety – all chemicals are contained in the system, minimizing the user’s exposure
  • Set-up reaction in less than 5 minutes
  • Small footprint
  • Plug & Play system – simple installation
  • Reaction temperatures from 25 °C – 80 °C
  • Cartridges available for many different reactions
  • Prefilled with all required reagents
  • RFID chip containing optimized reaction protocol

Legal Information

Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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