05-446
Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4
clone A16/17, Upstate®, from mouse
Synonym(s):
p75 Low Affinity Neurotrophin Receptor, NGFR
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
A16/17, monoclonal
species reactivity
monkey, human
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
neutralization: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... NGFR(4804)
Specificity
low affinity p75NTR
Immunogen
Human melanoma cell line WM245.
Application
Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4 detects level of p75NTR (Neurotrophin Receptor) & has been published & validated for use in IP, WB, IH, NEUT.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Kinases & Phosphatases
Neurodegenerative Diseases
Kinases & Phosphatases
Neurodegenerative Diseases
Quality
routinely evaluated by immunoblot on RIPA lysates from HS294T cells
Target description
69kDa
Linkage
Replaces: 04-1111
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Chromatography
Storage and Stability
2 years at -20°C
Other Notes
Due to license agreement restrictions, this product cannot be purchased for resale.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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S M Mooney et al.
Neuroscience, 149(2), 372-381 (2007-09-18)
Organotypic cultures of rat cortex were used to test the hypotheses that nerve growth factor (NGF) is neuroprotective for immature cortical neurons and that ethanol abolishes this neuroprotection in a developmental stage-dependent manner. Samples were obtained on gestational day (G)
Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats--possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor.
Fang Li,Li Li,Xing-Yun Song,Jin-Hua Zhong,Xue-Gang Luo,Cory J Xian,Xin-Fu Zhou
The European Journal of Neuroscience null
J Du et al.
The Journal of cell biology, 150(6), 1423-1434 (2000-09-20)
Brain-derived neurotrophic factor (BDNF) has been shown to regulate neuronal survival and synaptic plasticity in the central nervous system (CNS) in an activity-dependent manner, but the underlying mechanisms remain unclear. Here we report that the number of BDNF receptor TrkB
Angela L M Johnston et al.
PLoS biology, 5(8), e212-e212 (2007-08-19)
The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional therapies. Using a novel invasive glioma mouse model established by serial in vivo selection, we identified the p75
C Dominici et al.
Journal of neuro-oncology, 31(1-2), 57-64 (1997-01-01)
In neuroblastoma, high levels of mRNA for p140trkA and p75LNGFR neurotrophin receptors are predictive of favorable outcome. Their evaluation by Northern blot, however, requires substantial amounts of tissue and this prevents their routine evaluation as well as the possibility for
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