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850081P

Avanti

Monolyso Heart CA

Avanti Research™ - A Croda Brand 850081P, powder

Synonym(s):

monolysocardiolipin (Heart, Bovine) (sodium salt)

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About This Item

CAS Number:
383907-65-1
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (850081P-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850081P

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P([O-])(OC[C@]([H])(O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O.[Na+].[Na+]

General description

Monolysocardiolipin (MLCL) is a class of phospholipid related to cardiolipin. MLCL is a triacylated phospholipid, uncommon in bacterial or eukaryotic membranes. MLCL is prepared from cardiolipin by the hydrolysis action of phospholipase A2 (PLA2).

Application

Monolyso Heart CA is suitable for use:
  • as substrate for the synthesis of cardiolipin by the enzyme acyl-CoA:lysocardiolipin acyltransferase (ACLAT1)
  • as substrate for the assay of mitochondrial monolysocardiolipin acyltransferase (MLCL AT) activity
  • in the preparation of affinity resin MLCL-adriamycin-agarose for the purification of MLCL AT

Biochem/physiol Actions

Monolysocardiolipin (MLCL) is a substrate for the biosynthesis of cardiolipin in heart by the activity of MLCL acyltransferase. MLCL is a marker for Barth syndrome. MLCL is implicated in apoptosis.

Packaging

5 mL Clear Glass Sealed Ampule (850081P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cardiolipin solution from bovine heart 4.7-5.3 mg/mL in ethanol, ≥97% (TLC)

Sigma-Aldrich

C1649

Cardiolipin solution from bovine heart

Monolysocardiolipin: improved preparation with high yield
Kim J and Hoppel CL
Journal of Lipid Research, 52(2), 389-392 (2011)
Identification of unique cardiolipin and monolysocardiolipin species in Acinetobacter baumannii
Lopalco P, et al.
Scientific Reports, 7(1), 2972-2972 (2017)
Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)
Taylor WA and Hatch GM
The Journal of Biological Chemistry, 284(44), 30360-30371 (2009)
Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart
Mutter T, et al.
The Biochemical Journal, 346(2), 403-406 (2000)
Monolysocardiolipin in cultured fibroblasts is a sensitive and specific marker for Barth Syndrome
Van Werkhoven MA, et al.
Journal of Lipid Research, 47(10), 2346-2351 (2006)
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