808865
Gold nanoparticles
40 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O
Synonym(s):
Biotin Gold
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About This Item
UNSPSC Code:
12141717
NACRES:
NA.23
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material
PEG 5000
Quality Level
form
dispersion in H2O
nanoparticles
composition
, 3.58E12 particles/mL
packaging
pkg of 0.5 mL
storage condition
do not freeze
concentration
2.33 mg/mL in H2O
OD
50
surface area
7.74 m2/g
diameter
40 nm
pH
5-7
density
1.00 g/cm3
peak SPR wavelength
530 nm
functional group
biotin
storage temp.
2-8°C
InChI
1S/Au
InChI key
PCHJSUWPFVWCPO-UHFFFAOYSA-N
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General description
Gold nanoparticles PEG 5000 biotin terminated.The preparation of biotinylated gold nanoparticles involves two surface modification steps. First the carboxyl-terminated alkanethiol is attached to the surface of gold nanoparticles via chemisorption in the presence of a stabilizing agent. This step is followed by the reaction of the carboxyl groups with (+)-biotinyl-3,6,9,-trioxaundecanediamine and 2-(2-aminoethoxy)ethanol.
Application
Biotin functionalized gold nanoparticles are suitable for binding of streptavidin labelled conjugates. The gold nanoparticle label allows for straightforward detection of streptavidin by measuring the increase in absorbance of the sample upon binding. The absorption maximum is gold nanoparticle size dependent and ranges from 515-520nm for a 5nm particle to 572nm for a 100nm particle.
Gold nanoparticles 40 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O can be used as a theranostic agent for potential usage in cancer therapy and treatment of COVID-19. It can also be used in the detection of pathogens for biosensing applications. AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.
Legal Information
Product of CytoDiagnostics, Inc.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Controlled and reversible aggregation of biotinylated gold nanoparticles with streptavidin.
Aslan K, et al.
The Journal of Physical Chemistry B, 108(40), 15631-15639 (2004)
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
Heo DN, et al.
Biomaterials, 33(3), 856-866 (2012)
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 33(6), 666-680 (2020)
Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients
Itani R, et al.
Theranostics, 10(13), 5932-5932 (2020)
Localized surface plasmon resonance (LSPR) of polyelectrolyte-functionalized gold-nanoparticles for bio-sensing
Li X, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 332(2-3), 172-179 (2009)
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