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517925

Sigma-Aldrich

4′-Methylpropiophenone

90%, technical grade

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About This Item

Linear Formula:
CH3C6H4COC2H5
CAS Number:
5337-93-9
Molecular Weight:
148.20
EC Number:
226-267-5
MDL number:
MFCD00009312
UNSPSC Code:
12352100
PubChem Substance ID:
24873986
NACRES:
NA.22
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grade

technical grade

Assay

90%

refractive index

n20/D 1.528 (lit.)

bp

238-239 °C (lit.)

density

0.993 g/mL at 25 °C (lit.)

functional group

ketone

SMILES string

CCC(=O)c1ccc(C)cc1

InChI

1S/C10H12O/c1-3-10(11)9-6-4-8(2)5-7-9/h4-7H,3H2,1-2H3

InChI key

PATYHUUYADUHQS-UHFFFAOYSA-N

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Application

4′-Methylpropiophenone can be used as a building block to synthesize:
  • N





  • -(4-Chlorophenyl)-N′-[1-(4-methylphenyl)propyl]urea as a potential CRAC channel inhibitor.[1]
  • Mono and trinuclear cobaloxime/organocobaloxime complexes, which are used as efficient catalysts for the synthesis of cyclic carbonates.[2]
  • Tolperisone (TOL) via acid-catalyzed reaction with piperidine hydrochloride and 1,2-dioxolane.[3]

Other Notes

Remainder 3′-methylpropiophenone

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

228.2 °F - closed cup

Flash Point(C)

109.00 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBS5733V
MKBS5734V
MKBS0722V
MKBQ2645V
MKBP0477V

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TLC-densitometric determination of tolperisone and its impurities 4-methylpropiophenone and piperidine in pharmaceutical preparations
Hubicka U, et al.
Journal of Liquid Chromatography and Related Technologies, 35(10), 1325-1335 (2012)
Paul I Dargan et al.
Drug testing and analysis, 3(7-8), 454-463 (2011-07-15)
Mephedrone (4-methylmethcathinone) is a synthetic cathinone that is used as a recreational drug. It has been available since 2007 but its availability and use increased significantly during 2009 and 2010. In this review article we will summarize the available literature
Ketone synthesized cobaloxime/organocobaloxime catalysts for cyclic carbonate synthesis from CO2 and epoxides: Characterization and electrochemistry
Kilic A, et al.
Journal of Organometallic Chemistry, 767, 150-159 (2014)
Alkaloid induced asymmetric electrocarboxylation of 4-methylpropiophenone.
Zhao SF, et al.
Tetrahedron Letters, 52(21), 2702-2705 (2011)
Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl) urea derivatives as novel inhibitors of CRAC channel
Zhang Hai-zhen, et al.
Acta Pharmacologica Sinica, 36(9), 1137-1144 (2015)
View All Related Papers

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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