Methods and findings in experimental and clinical pharmacology, 5(4), 251-254 (1983-01-01)
The effects of GABA, its quaternary derivative N-trimethyl GABA and quinidine have been studied in a model of ventricular automaticity induced in the isolated right ventricle of the rat. GABA shows low anti-automatic activity. N-trimethyl GABA and quinidine were, however
The Biochemical journal, 361(Pt 3), 417-429 (2002-01-23)
Carnitine is indispensable for energy metabolism, since it enables activated fatty acids to enter the mitochondria, where they are broken down via beta-oxidation. Carnitine is probably present in all animal species, and in numerous micro-organisms and plants. In mammals, carnitine
Biochimica et biophysica acta, 797(1), 136-139 (1984-01-24)
The effect of ascorbate deficiency on carnitine biosynthesis was investigated in young male guinea pigs. Liver and skeletal muscle carnitine levels were reduced in scorbutic animals. Heart and kidney concentrations remained unchanged. 14C-labeled 4-N-trimethylaminobutyrate was administered to control, pair-fed and
The biosynthesis of carnitine proceeds from trimethyllysine (TML) by beta-hydroxylation by a liver or kidney mitochondrial enzyme, which requires oxygen, alpha-ketoglutarate, ferrous iron, and ascorbate. This dioxygenase is rapidly inactivated by preincubation with Fe2+, but not Fe3+. The evidence suggests
Biochimica et biophysica acta, 886(3), 425-433 (1986-05-29)
Uptake and metabolism of L-carnitine, D-carnitine and acetyl-L-carnitine were studied utilizing isolated guinea-pig enterocytes. Uptake of the D- and L-isomers of carnitine was temperature dependent. Uptake of L-[14C]carnitine by jejunal cells was sodium dependent since replacement by lithium, potassium or
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