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282197

Sigma-Aldrich

Carvacrol

98%

Synonym(s):

5-Isopropyl-2-methylphenol

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About This Item

Linear Formula:
(CH3)2CHC6H3(CH3)OH
CAS Number:
499-75-2
Molecular Weight:
150.22
Beilstein:
1860514
EC Number:
207-889-6
MDL number:
MFCD00002236
UNSPSC Code:
12352100
PubChem Substance ID:
24857025
NACRES:
NA.22
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Assay

98%

form

liquid

refractive index

n20/D 1.522 (lit.)

bp

236-237 °C (lit.)

mp

3-4 °C (lit.)

density

0.976 g/mL at 20 °C (lit.)

SMILES string

CC(C)c1ccc(C)c(O)c1

InChI

1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3

InChI key

RECUKUPTGUEGMW-UHFFFAOYSA-N

Gene Information

human ... UGT1A4(54657)

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General description

Carvacrol is a monoterpenic phenol produced by aromatic plants, thyme and oregano[1]. Carvacrol has been evaluated as alternatives to antibiotic feed additives in female broiler chickens[2].

Application

Carvacrol has been used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations[1].

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Signal Word

Danger

Hazard Statements

H302,H314,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

>212.0 °F

Flash Point(C)

> 100 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBL0703
STBK7742
STBK3476
STBJ9333
STBJ4953

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Sigma-Aldrich

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Sigma-Aldrich

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Antibacterial activity of carvacrol, citral, and geraniol against Salmonella typhimurium in culture medium and on fish cubes.
Kim JM, et al.
Journal of Food Science, 60(6), 1364-1368 (1995)
A Ultee et al.
Journal of applied microbiology, 85(2), 211-218 (1998-09-29)
Carvacrol, a natural plant constituent occurring in oregano and thyme, was investigated for its bactericidal effect towards the food-borne pathogen Bacillus cereus. Carvacrol showed a dose-related growth inhibition of B. cereus. At concentration of 0.75 mmol l-1 and above, total
Zacharias E Suntres et al.
Critical reviews in food science and nutrition, 55(3), 304-318 (2014-06-11)
Carvacrol is a monoterpenic phenol produced by an abundant number of aromatic plants, including thyme and oregano. Presently, carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations.
Dietary carvacrol lowers body weight gain but improves feed conversion in female broiler chickens.
Lee K-W, et al.
The Journal of Applied Poultry Research, 12(4), 394-399 (2003)
S Ananda Baskaran et al.
Journal of dairy science, 92(4), 1423-1429 (2009-03-25)
The objective of this study was to investigate the antimicrobial effect of plant-derived antimicrobials including trans-cinnamaldehyde (TC), eugenol, carvacrol, and thymol on major bacterial mastitis pathogens in milk. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What is the vehicle of the carvacrol? Is Salin used as a suspended material?

    1 answer

    1. This product is a neat or pure liquid with a minimum purity of 98% and a density of 0.976 g/mL. This item is not tested for solubility. However, Flavors & Fragrance product W224502 is soluble at 1ml/4ml of 60% Ethanol. Similar or identical solubility rates would be expected.

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