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Merck

1347700

USP

Irbesartan

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one

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About This Item

Fórmula empírica (notación de Hill):
C25H28N6O
Número de CAS:
Peso molecular:
428.53
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

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grade

pharmaceutical primary standard

API family

irbesartan

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5

InChI

1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChI key

YOSHYTLCDANDAN-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

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Este artículo
Y0001166BP1093PHR1443
Irbesartan United States Pharmacopeia (USP) Reference Standard

1347700

Irbesartan

Irbesartan European Pharmacopoeia (EP) Reference Standard

Y0001166

Irbesartan

Irbesartan British Pharmacopoeia (BP) Reference Standard

BP1093

Irbesartan

Irbesartan Pharmaceutical Secondary Standard; Certified Reference Material

PHR1443

Irbesartan

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

irbesartan

API family

irbesartan

API family

irbesartan

API family

irbesartan

Gene Information

human ... AGTR1(185)

Gene Information

human ... AGTR1(185)

Gene Information

human ... AGTR1(185)

Gene Information

human ... AGTR1(185)

Application

Irbesartan USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Irbesartan Tablets
  • Irbesartan and Hydrochlorothiazide Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


  • Certificados de análisis (COA)

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    Visite la Librería de documentos

    J C Gillis et al.
    Drugs, 54(6), 885-902 (1998-01-09)
    Irbesartan inhibits the activity of angiotensin II (AII) via specific, selective noncompetitive antagonism of the AII receptor subtype 1 (AT1) which mediates most of the known physiological activities of AII. In patients with mild to moderate hypertension, once daily administration
    Giuseppe Derosa et al.
    Current vascular pharmacology, 7(2), 120-136 (2009-04-10)
    Blood pressure (BP) is one of the most important and common vascular risk factors but it is often poorly controlled. Inhibition of the renin-angiotensin-aldosterone system (RAAS) provides beneficial effects in hypertensives. The association of low-dosed diuretics in combination with RAAS
    Peter Bramlage et al.
    Expert opinion on pharmacotherapy, 11(4), 521-535 (2009-12-25)
    Guidelines recommend five antihypertensive drug classes, but which particular drug to choose is up to the treating physician. We aimed at an in-depth comparison of two frequently used angiotensin receptor blockers to provide evidence for this decision. Pharmacology of irbesartan
    A J Palmer et al.
    International journal of clinical practice, 61(10), 1626-1633 (2007-09-20)
    The objective of the study was to determine the impact of irbesartan treatment on life expectancy (LE), costs and progression to end-stage renal disease (ESRD) in hypertensive type 2 diabetes patients. A peer-reviewed and published Markov model was used to
    J M Flack
    International journal of clinical practice, 61(12), 2093-2102 (2007-09-25)
    Evidence-based guidelines for the management of hypertension are now well established. Studies have shown that more than 60% of patients with hypertension will require two or more drugs to achieve current treatment targets. Combination therapy is recommended as first-line treatment

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