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Merck

1075757

USP

Bisoprolol fumarate

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

Bisoprolol hemifumarate salt, 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate salt

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About This Item

Fórmula empírica (notación de Hill):
C18H31NO4 · .5C4H4O4
Número de CAS:
Peso molecular:
383.48
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

bisoprolol

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1.CC(C)NCC(O)COc2ccc(COCCOC(C)C)cc2

InChI

1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+

InChI key

VMDFASMUILANOL-WXXKFALUSA-N

Gene Information

human ... ADRB1(153)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application


  • Chromatographic Techniques for Assessment of Bisoprolol Fumarate and Perindopril Arginine in Solid Formulations under Various Stress Conditions and Application to Six Sigma, Content Uniformity, and Comparative Dissolution Approaches - Presents advanced chromatographic methods to assess Bisoprolol fumarate in pharmaceutical formulations, crucial for ensuring high standards in drug quality and stability (Mahmoud OA et al., 2023).

Biochem/physiol Actions

Cardioselective β1-adrenoceptor antagonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - STOT RE 2

target_organs

Heart

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Bisoprolol Fumarate Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(5) (2013)
Bisoprolol Fumarate and Hydrochlorothiazide Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(2) (2013)
Naseem A Charoo et al.
Journal of pharmaceutical sciences, 103(2), 378-391 (2014-01-03)
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing bisoprolol as the sole active pharmaceutical ingredient (API) are reviewed. Bisoprolol is classified
In reply.
Catherine Ashes et al.
Anesthesiology, 120(5), 1287-1288 (2014-04-24)
Does β selectivity really affect outcome?
Jordan Field Wicker et al.
Anesthesiology, 120(5), 1286-1287 (2014-04-24)

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