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Merck

T7941

Sigma-Aldrich

Monoclonal Anti-β-Tubulin IV antibody produced in mouse

clone ONS.1A6, ascites fluid

Sinónimos:

Anti-DYT4, Anti-TUBB4, Anti-beta-5

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

ascites fluid

tipo de anticuerpo

primary antibodies

clon

ONS.1A6, monoclonal

mol peso

antigen ~55 kDa

reactividad de especies

hamster, chicken, human, bovine, rat, mouse

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:400 using cultured human breast adenocarcinoma cell line MCF-7

isotipo

IgG1

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... TUBB4(10382)
mouse ... Tubb4(22153)
rat ... Tubb4(29213)

Descripción general

β-Tubulin IV codes for β-tubulin 4A (TUBB4A). TUBB4A is expressed in the central nervous system by oligodendrocytes. It is located on human chromosome 19p13.3.
Microtubules are heterodimeric proteins that comprise of α- and β-tubulins. β-tubulins have four different isotypes in brain cells, ranging from β I to β IV . Anti-tubulin antibodies are useful to study the localization of tubulin proteins. Monoclonal Anti-β-Tubulin IV antibody is specific for epitope located in the C-terminal sequence of β-tubulin isotype IV in humans, bovines, hamsters, rats, mice and chickens. The product does not react with other tubulin isotypes.

Inmunógeno

synthetic peptide corresponding to the C-terminal sequence of β-tubulin isotype IV, conjugated to BSA.

Aplicación

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-β-Tubulin IV antibody has been used in immunostaining.
Monoclonal Anti-β-Tubulin IV antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections), indirect ELISA, microarray and western blot (1:400 using cultured human breast adenocarcinoma cell line MCF-7). The product may also be used for immunocytochemistry and immunofluorescence .

Acciones bioquímicas o fisiológicas

β-Tubulin IV creates the oligodendrocyte microtubule network, that helps in the transport of myelin proteins, lipids and RNA at the time of myelination. It participates in the generation of early fibrotic stages. TUBB4 plays a major role in the transport and proper localization of N-cadherin within the plasma membrane.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages
Wawro M E, et al.
Cellular Signalling, 38(3), 26-38 (2017)
beta IV tubulin is selectively expressed by oligodendrocytes in the central nervous system
Terada N, et al.
Glia, 50(3), 212-222 (2005)
Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice
Takaki E, et al.
The Journal of Biological Chemistry, 282(51), 37285-37292 (2007)
The many faces of TUBB4A mutations
Lohmann K and Klein C
Neurogenetics, 15(2), 81-81 (2014)
Shubing Zhang et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 242(6), 678-686 (2013-03-26)
The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch-mediated signals involved in lung development remain unclear. Here we report that Jagged1 is expressed in a

Artículos

Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.

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