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Merck
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Key Documents

SRP6370

Sigma-Aldrich

Aldolase A human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinónimos:

ALDA, ALDOA, Fructose bisphosphate Aldolase A, GSD12

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

liquid

mol wt

41.5 kDa (384 aa, 1-364 aa + His Tag)

packaging

pkg of 100 μg

concentration

1 mg/mL

UniProt accession no.

P04075

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ALDOA(226)

General description

Aldolase A (ALDOA) is a ubiquitous glycolytic enzyme expressed in developing embryos and in adult muscles. The gene encoding it is localized on human chromosome 16p11.2. Recombinant human Aldolase A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Biochem/physiol Actions

In glycolysis, aldolase A (ALDOA) catalyzes the reversible reaction of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. It is involved in a wide range of cellular functions such as maintenance of striated muscle contraction, cell shape and mobility, actin filament organization and ATP biosynthetic process. High expression level of ALDOA is reported in various forms of malignant cancers, including human lung squamous, renal cell and hepatocellular carcinomas. ALDOA deficiency causes myopathy and hemolytic anemia.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl and 10% glycerol.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Comparative proteomics analysis of gastric cancer stem cells.
Morisaki T
PLoS ONE, 9(14) (2014)
Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation.
Kishi H
Proceedings of the National Academy of Sciences of the USA, 84(23) (1987)
Association and Mutation Analyses of 16p11.2 Autism Candidate Genes
Ravinesh A
PLoS ONE (2009)
Two cases of red cell aldolase deficiency associated with hereditary hemolytic anemia in a Japanese family.
Miwa S
American Journal of Hematology, 11(4) (1981)
Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration.
Sha Du
PLoS ONE, 9(9) (2014)

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