SRP6007
NT-3 from mouse
recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
Sinónimos:
HDNF, NGF-2, NT-3, Nerve growth factor-2, Neurotrophic factor
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
origen biológico
mouse
recombinante
expressed in E. coli
Ensayo
≥97% (HPLC)
≥97% (SDS-PAGE)
Formulario
lyophilized
mol peso
13.6 kDa
envase
pkg of 10 μg
impurezas
Endotoxin, tested
Nº de acceso NCBI
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... NTF3(18205)
Descripción general
NT-3 (neurotrophin-3) is a member of the family of trophic factors, called neurotrophins. This family also includes NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. NT-3 is the most abundantly expressed neurotrophin during early development.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.
Aplicación
NT-3 (neurotrophin-3) has been used for the ex vivo treatment of skin punches obtained from rat and human samples.
Acciones bioquímicas o fisiológicas
Study in mice show that NT-3 (neurotrophin-3), along with BDNF (brain-derived neurotrohpic factor), is essential for inner ear development. In vitro motor, enteric, primary sensory, sympathetic, locus coeruleus, cerebellar and hippocampal neurons are responsive to NT-3. Mice null for NT-3 show significant deficiency in sympathetic and sensory nerve populations. In mice, post birth up-regulation of NT-3 induces a second wave of dopaminergic amacrine cell genesis.
Forma física
Sterile filtered and lyophilized powder
Reconstitución
Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Overexpression of neurotrophin-3 stimulates a second wave of dopaminergic amacrine cell genesis after birth in the mouse retina.
Yoshida M et al
The Journal of Neuroscience, 31(35), 12663-12673 (2011)
Complementary roles of BDNF and NT-3 in vestibular and auditory development.
Ernfors P et al
Neuron, 14(6), 1153-1164 (1995)
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.
Fari?as I et al
Nature, 369(6482), 658-661 (1994)
Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.
Price EA et al
Journal of Neuroscience Methods, 282, 34-42 (2017)
Shyan-Yuan Kao et al.
Bone, 145, 115837-115837 (2021-01-02)
The bone encasing the inner ear, known as the otic capsule, is unique because it remodels little postnatally compared to other bones in the body. Previous studies established that osteoprotegerin (OPG) in the inner ear inhibits otic capsule remodeling. OPG
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