SRP4702

CTGF human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• Sinónimos: connective tissue growth factor
• Número MDL: MFCD07370810
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: human
• recombinante: expressed in E. coli
• Ensayo: ≥95% (HPLC); ≥95% (SDS-PAGE)
• Formulario: lyophilized
• potencia: 501.0-2.0 μg/mL ED₅₀
• mol peso: ~11.2 kDa
• envase: pkg of 20 μg
• impurezas: endotoxin, tested
• Nº de acceso NCBI: NM_001901
• Nº de acceso UniProt: P29279
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... CTGF(1490)

Descripción

Descripción general

The gene CTGF (connective tissue growth factor) is mapped to human chromosome 6q23.2. CTGF is a member of the CCN (Cyr61, CTGF , Nov) family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. The protein has an N-terminal secretory signal peptide and four domains (an insulin-like growth factor-binding protein domain, a Von Willebrand factor domain, a thrombospondin type-1 repeat module, and a CT). It is expressed in various tissues, such as connective tissue, heart, brain, kidney, lung, liver, muscle, pancreas gland and placenta. Recombinant human CTGF is a 11.2Da protein of 98 amino acid residues.

Acciones bioquímicas o fisiológicas

CTGF (connective tissue growth factor) stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells. It binds to IGF (insulin growth factor), TGF (transforming growth factor) β1 and BMP (bone morphogenetic protein)-4. CTGF plays a crucial role in the progression of diabetic nephropathy. It can work as an oncoprotein in glioma and melanoma. However, it works as a tumor suppressor in lung cancer and colon cancer.

Forma física

Sterile filtered and Lyophilized without additives.

Reconstitución

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable