SML2948
Mca-APK(Dnp)-OH trifluoroacetate
≥97% (HPLC)
Sinónimos:
Mca-APK(Dnp) TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl), Mca-Ala-Pro-Lys(Dnp) TFA salt, Mca-Ala-Pro-Lys(Dnp)-OH TFA salt
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About This Item
Fórmula empírica (notación de Hill):
C32H36N6O12 · xC2HF3O2
Peso molecular:
696.66 (free base basis)
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Ensayo
≥97% (HPLC)
Formulario
film or powder
condiciones de almacenamiento
desiccated
color
white to dark beige
temp. de almacenamiento
−20°C
Acciones bioquímicas o fisiológicas
Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity.
Popular fluorescent substrate for angiotensin-converting enzyme 2 (ACE2).
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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A P O Leite et al.
Journal of cellular physiology, 234(12), 22809-22818 (2019-05-28)
Diabetes mellitus and its complications have become a major health concern in Western countries. Increased activity of the intrarenal renin-angiotensin system (RAS) contributes to diabetic nephropathy (DN). We previously reported that in mesangial cells, the high glucose concentration (HG) leads
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