Saltar al contenido
Merck

SML2370

Sigma-Aldrich

Dabigatran

≥95% (HPLC)

Sinónimos:

BIBR-953, N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Fórmula empírica (notación de Hill):
C25H25N7O3
Número de CAS:
Peso molecular:
471.51
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77

Ensayo

≥95% (HPLC)

Formulario

powder

color

white to beige

solubilidad

0.1 M HCl: 2 mg/mL, clear

temp. de almacenamiento

2-8°C

cadena SMILES

N=C(N)C(C=C1)=CC=C1NCC(N2C)=NC3=C2C=CC(C(N(CCC(O)=O)C4=NC=CC=C4)=O)=C3

InChI

1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)

Clave InChI

YBSJFWOBGCMAKL-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

Dabigatran is a nonpeptide direct thrombin inhibitor. It is an anticoagulant that functions by directly inhibiting both free and fibrin-bound thrombin. Dabigatron has been shown to prevent strokes in those with atrial fibrillation not caused by heart valve issues.
Nonpeptide, direct thrombin inhibitor

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Damon Klebe et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(9), 3135-3149 (2017-02-06)
We aim to determine if direct thrombin inhibition by dabigatran will improve long-term brain morphological and neurofunctional outcomes and if potential therapeutic effects are dependent upon reduced PAR-1 stimulation and consequent mTOR activation. Germinal matrix haemorrhage was induced by stereotaxically
Giuseppe Femia et al.
Heart, lung & circulation, 27(7), 798-803 (2017-08-15)
For some patients with atrial fibrillation, direct current cardioversion (DCCV) is one strategy that can be used to establish sinus rhythm but appropriate anticoagulation is mandatory to prevent thromboembolic events. Historically, patients were anticoagulated with warfarin with bridging with unfractionated
Wolfgang G Eisert et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(10), 1885-1889 (2010-07-31)
Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response. Peak
Hao Zhang et al.
Frontiers in cellular and infection microbiology, 11, 677902-677902 (2021-08-03)
Patients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported. However, the role of circulating NETs in the progression and thrombotic tendency of sepsis-induced lung injury
Gut microbial I?-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Edwinson, et al.
Nature microbiology, 7, 680-694 (2022)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico