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Merck
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Documentos clave

SML0915

Sigma-Aldrich

Xipamide

≥98% (HPLC)

Sinónimos:

5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide, BE 1293, BEI 1293, MJF 10938

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About This Item

Fórmula empírica (notación de Hill):
C15H15ClN2O4S
Número de CAS:
14293-44-8
Peso molecular:
354.81
EC Number:
238-216-4
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

InChI

1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)

InChI key

MTZBBNMLMNBNJL-UHFFFAOYSA-N

Biochem/physiol Actions

Xipamide is a sulfonamide diuretic that blocks sodium reabsorption in the distal tubules of the kidney, resulting in increased urine output. Xiopamide also blocks the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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[Diuretic therapy: renaissance of time-tested therapeutic principles].
Der Internist, 33(10 Suppl), 1-8 (1992-10-01)
P Lijnen et al.
Cardiovascular drugs and therapy, 5(4), 741-746 (1991-08-01)
The effect of xipamide on plasma alpha-atrial natriuretic peptide and the renin-aldosterone-kallikrein system have been studied in 12 healthy men, using a double-blind cross-over design. After a run-in period on placebo of 1 week, the subjects were treated with either
Ahmed S Al-Kady
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 284-289 (2012-07-10)
A simple, selective and sensitive spectrophotometric method for the determination of trace amounts of Zr(IV) in aqueous samples was performed, based on complexation reaction between Zr(IV) and 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide (xipamide). The important analytical parameters and their effects on the reported system
Heinrich Knauf et al.
Arzneimittel-Forschung, 55(1), 1-14 (2005-02-25)
Xipamide (CAS 14293-44-8) shows structural features comparable with the thiazide- as well as the class of loop diuretics. According to earlier findings this diuretic, in contrast to the thiazides, should not decrease the glomerular filtration rate (GFR) and be effective
Iatrogenic hypercalcaemia, hypokalaemia and metabolic alkalosis in a lady with vena cava thrombosis--beware of overzealous diuretic treatment.
G A Böhmig et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 14(3), 782-784 (1999-04-08)
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