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Merck
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Documentos clave

SML0540

Sigma-Aldrich

Oxyphenbutazone

≥98% (HPLC)

Sinónimos:

4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione, G 27202, NSC 526053, Ro 04-4410, p-Hydroxyphenylbutazone, p-Oxyphenylbutazone

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About This Item

Fórmula empírica (notación de Hill):
C19H20N2O3
Número de CAS:
129-20-4
Peso molecular:
324.37
Código UNSPSC:
12352200
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

condiciones de almacenamiento

desiccated

color

white to brown

solubilidad

DMSO: 10 mg/mL, clear

temp. de almacenamiento

−20°C

cadena SMILES

N2(N(C(=O)C(C2=O)CCCC)c3ccccc3)c1ccc(cc1)O

InChI

1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3

Clave InChI

HFHZKZSRXITVMK-UHFFFAOYSA-N

Descripción general

Oxyphenbutazone is a derivative compound of phenylbutazone.

Acciones bioquímicas o fisiológicas

Oxyphenbutazone is a non-steroid anti inflammatory; anti Mycobacterium tuberculosis agent.
Oxyphenbutazone is a non-steroid anti inflammatory; anti Mycobacterium tuberculosis agent. Oxyphenbutazone is known to cause inflammatory effects on tissues. Oxyphenbutazone, as a drug, decreases cellular exudates, without involving the pituitary-adrenal axis or the immunity response. Though the drug delivers a number of side effects, it is considered to be less toxic than phenylbutazone, due to decreased rate of intestinal absorption.
Oxyphenbutazone is an NSAID that has been shown to preferentially kill non-replicating Mycobaterium tuberculosis maintained in media that simulates the mildly acidic, in vivo conditions where drug-resistant, non replicating subpopulations of the bacteria reside in hosts. The compound has little or no affect on replication M. tuberculosis grown in normal liquid cultures.

Otras notas

Air sensitive

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palabra de señalización

Warning

Frases de peligro

H302,H400

Consejos de prudencia

P273 - P301 + P312 + P330

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Acute 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000419848
0000419848
0000305972
0000305976
0000305975

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N S Matthews et al.
American journal of veterinary research, 62(5), 673-675 (2001-05-09)
To describe the pharmacokinetics of phenylbutazone and oxyphenbutazone after IV administration in miniature donkeys. 6 clinically normal miniature donkeys. Blood samples were collected before and 5, 10, 20, 30, 45, 60, 90, 120, 180, 240, 300, 360, and 480 minutes
Aik-Jiang Lau et al.
Journal of pharmaceutical and biomedical analysis, 31(2), 401-406 (2003-03-01)
Adulterations with synthetic drugs are common problems with herbal medicine and this can potentially cause serious adverse effects. It is therefore important to determine the presence of synthetic drugs in herbal medicine to ensure patients' safety. The objective of this
Youwen You et al.
Journal of analytical toxicology, 33(1), 41-50 (2009-01-24)
A sensitive liquid chromatographic-tandem mass spectrometric method was developed and validated for screening, quantification, and confirmation of phenylbutazone and oxyphenbutazone in equine plasma. Analytes were recovered from plasma by liquid-liquid extraction followed by separation in a reversed-phase column and identification
A Kadir et al.
Journal of veterinary pharmacology and therapeutics, 20(1), 54-60 (1997-02-01)
Phenylbutazone was administered intravenously and intramuscularly at a dosage rate of 4.4 mg/kg to a group of 6 female camels in a two-period crossover study. After intravenous (i.v.) administration, disposition was characterised by a two-compartment open model, with a low
E Pesce et al.
Research communications in molecular pathology and pharmacology, 115-116, 39-48 (2007-06-15)
The antirheumatic effect of pirfenidone was compared with a positive control drug, oxyphenbutazone which is used in patients suffering from rheumatoid arthritis, in a double blind clinical trial in humans. The data collected in this pilot project revealed that pirfenidone
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