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SML0320

Sigma-Aldrich

FR180204

≥98% (HPLC)

Sinónimos:

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine, 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine, FR 180204

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About This Item

Fórmula empírica (notación de Hill):
C18H13N7
Número de CAS:
865362-74-9
Peso molecular:
327.34
MDL number:
MFCD14585805
UNSPSC Code:
12352200
PubChem Substance ID:
329825325
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5

InChI

1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)

InChI key

XVECMUKVOMUNLE-UHFFFAOYSA-N

Application

FR180204 has been used as ERK inhibitor:
  • to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
  • of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
  • to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy

Biochem/physiol Actions

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).
It can be used to study the roles of ERK as well as for drug development.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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PD 98,059 solid

Sigma-Aldrich

P215

PD 98,059

LY-294,002 hydrochloride solid, ≥98% (HPLC)

Sigma-Aldrich

L9908

LY-294,002 hydrochloride

U0126 U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Sigma-Aldrich

19-147

U0126

Gefitinib ≥98% (HPLC)

Sigma-Aldrich

SML1657

Gefitinib

SB 203580 solid, ≥98% (HPLC)

Sigma-Aldrich

S8307

SB 203580

The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia
Gupta N, et al.
Stem Cells, 36(5), 796-806 (2018)
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Ohori M, et al.
Biochemical and biophysical research communications, 336(1), 357-363 (2005)
Mario Sechi et al.
Scientific reports, 8(1), 15726-15726 (2018-10-26)
The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transition and its inhibition
Miho Tanaka et al.
Cancer research, 78(13), 3589-3603 (2018-04-25)
Natural killer (NK) cells express receptors specific for MHC class I (MHC-I) molecules involved in "missing-self" recognition of cancer and virus-infected cells. Here we elucidate the role of MHC-I-independent NKR-P1B:Clr-b interactions in the detection of oncogenic transformation by NK cells.
Maren Bakkebø et al.
BMC immunology, 11, 57-57 (2010-11-26)
Cytokines of the transforming growth factor β (TGF-β) superfamily exert effects on proliferation, apoptosis and differentiation in various cell types. Cancer cells frequently acquire resistance to the anti-proliferative signals of TGF-β, which can be due to mutations in proteins of
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