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Key Documents

SAB5300028

Sigma-Aldrich

Monoclonal Anti-RAB10 antibody produced in mouse

clone 4E2, ascites fluid

Sinónimos:

RAB10

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

4E2, monoclonal

mol wt

22.5 kDa

species reactivity

mouse, human

technique(s)

direct ELISA: 1:10,000
indirect immunofluorescence: 1:200-1:1,000
western blot: 1:500-1:2,000

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... Rab10(10890)

General description

Rab10, a small monomeric Ras-related GTP-binding protein, is a member of the rat sarcoma (RAS) family. RAB10 gene has GTP and GDP binding domains. RAB10 gene is located on human chromosome 2p23.3.

Immunogen

Purified recombinant fragment of human Rab10 expressed in E.coli.
Mouse monoclonal antibody raised against Rab10

Application

Monoclonal Anti-RAB10 antibody produced in mouse has been used in western blotting (1:1000) and immunocytochemistry (1:1000).

Biochem/physiol Actions

RAB10 is involved in intracellular vesicle trafficking. It is important for insulin-stimulated glucose transporter type 4 (GLUT4) translocation in adipocytes, the secretion of the basement membrane, and endoplasmic reticulum development and maintenance (ER). It controls toll-like receptor 4 (TLR4) trafficking, which is crucial for innate immune responses. Rab10 gene knockdown reduces the production of Aβ and higher expression of Rab10 enhances amyloid β protein (Aβ) production in cultured neuroblastoma cells. Phosphorylation of Rab10 could be the cause of vesicle trafficking abnormalities that lead to neurodegeneration in Alzheimer′s disease. Overexpression of RAB10 is observed in hepatocellular carcinoma (HCC).

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Shea J Andrews et al.
Current genetic medicine reports, 7(1), 1-12 (2019-03-01)
Over the last decade over 40 loci have been associated with risk of Alzheimer's disease (AD). However, most studies have either focused on identifying risk loci or performing unbiased screens without a focus on protective variation in AD. Here, we
Yahaira Naaldijk et al.
NPJ Parkinson's disease, 10(1), 12-12 (2024-01-09)
Parkinson´s disease (PD) is a common neurodegenerative movement disorder and leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for disease intervention. However, the ability to stratify patients who will benefit from such treatment modalities based on shared etiology
Wei Wang et al.
Oncotarget, 8(16), 26434-26447 (2017-05-04)
Hepatocellular carcinoma (HCC), one of the most common and lethal cancers worldwide, has a high recurrence rate with current treatment modalities. Identifying biomarkers for early diagnosis and discovering new sufficient molecular targets for the development of targeted therapies are urgently
Tingxiang Yan et al.
Journal of Alzheimer's disease : JAD, 63(1), 157-165 (2018-03-23)
Alzheimer's disease (AD) is the leading cause of dementia in the elderly, characterized by neurofibrillary tangles (NFTs), senile plaques (SPs), and a progressive loss of neuronal cells in selective brain regions. Rab10, a small Rab GTPase involved in vesicular trafficking
Antonio Jesús Lara Ordónez et al.
Human molecular genetics, 28(21), 3552-3568 (2019-08-21)
Mutations in the LRRK2 kinase are the most common cause of familial Parkinson's disease, and variants increase risk for the sporadic form of the disease. LRRK2 phosphorylates multiple RAB GTPases including RAB8A and RAB10. Phosphorylated RAB10 is recruited to centrosome-localized

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