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Key Documents

SAB4502117

Sigma-Aldrich

Anti-RXFP3 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

G protein-coupled receptor SALPR, GPCR135, RLN3 receptor 1, Relaxin family peptide receptor 3, Somatostatin- and angiotensin-like peptide receptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 51 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RXFP3(51289)

Categorías relacionadas

General description

Anti-RXFP3 Antibody detects endogenous levels of total RXFP3 protein.
RXFP3 (relaxin family peptide receptor 3) is also termed as GPCR 135/ SALPR (somatostatin- and angiotensin- like peptide receptor). It is distributed in the central nervous system (CNS), mainly in areas associated with memory, sensory and emotional processing. RXFP3 belongs to the insulin superfamily. This gene is mapped to human chromosome 5p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human RXFP3.

Immunogen Range: 161-210

Biochem/physiol Actions

RXFP3 (relaxin family peptide receptor 3) acts as the cognate receptor for relaxin-3. It controls feeding, motivated behaviors, stress and anxiety. RXFP3 system also modulates alcohol-seeking.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Visite la Librería de documentos

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Jayakody T, et al.
Peptides, 84, 44-57 (2016)
In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.
Alvarez-Jaimes L, et al.
PLoS ONE, 7(2), e30792-e30792 (2012)
5p13. 3p13. 2 duplication associated with developmental delay, congenital malformations and chromosome instability manifested as low-level aneuploidy.
Iourov IY, et al.
SpringerPlus, 4(1), 616-616 (2015)
Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats.
Calvez J, et al.
Neuropharmacology, 102, 207-215 (2016)
Philip J Ryan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(51), 20789-20794 (2013-12-04)
Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. Using a rat model of alcohol use and alcohol-seeking, we demonstrated that central administration of peptide antagonists for relaxin family peptide 3 receptor

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