SAB4502020

Anti-NOTCH2 (Cleaved-Asp¹⁷³³) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Motch B, NOTC2, NOTCH2, NTC2, Neurogenic locus notch homolog protein 2 precursor
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 100 kDa; antigen 130 kDa
• species reactivity: human, rat, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: Q04721
• UniProt accession no.: Q04721
• application(s): research pathology
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: proteolytically cleaved (Asp1733)
• Gene Information: human ... NOTCH2(4853)

Descripción

General description

Anti-NOTCH2 (Cleaved-Asp¹⁷³³) antibody detects endogenous levels of fragment of activated NOTCH2 (Cleaved-Asp¹⁷³³) protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Notch 2.

Immunogen Range: 1684-1733

Biochem/physiol Actions

The NOTCH2 (notch2) gene is known to be involved in the proliferation, cell cycle progression and colony formation of cancer cells. Upregulation of the gene is observed in hepatocellular carcinoma and salivary adenoid cystic carcinoma. Deletion of NOTCH2 increases the sensitivity of the cancer cells to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable