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SAB4500362

Sigma-Aldrich

Anti-Collagen I antibody produced in rabbit

affinity isolated antibody

Sinónimos:

α 2 type i collagen, co1a2, col1a2, collagen, type i

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

antigen 129 kDa

reactividad de especies

mouse, human, rat

concentración

~1 mg/mL

técnicas

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... COL1A2(1278)

Descripción general

Collagen I is encoded by the gene COL1A2 (collagen type I alpha 2). The gene is located on human chromosome 7q21.3. COL1A2 is a fibril forming collagen, found in bone, dermis, tendon, ligaments and cornea.
Collagen is the major structural component of extracellular matrices found in connective tissues and internal organs, but is most prevalent in the dermis, tendons, and bones. It is classified into a number of structurally and genetically distinct types. Type I collagen is a heterodimer composed of two α1(I) chains and one α2(I) chain that spontaneously forms a triple helix scaffold at neutral pH and 37 °C. Collagen type I is an excellent substrate for the culture of hepatocytes, fibroblasts, spinal ganglion, muscle cells, Schwann cells, embryonic lung cells, epithelial cells, and a number of other cell lines. It has also been used in the study of growth, differentiation, migration of cell lines, and tissue morphogenesis during development.
Rabbit polyclonal anti-Collagen I, N-Terminal antibody reacts with mouse, rat, and human type I collagens.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human Collagen I.

Immunogen Range: 1-50

Aplicación

Anti-Collagen I antibody produced in rabbit has been used in western blotting and immunostaining.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Rabbit polyclonal anti-Collagen I, N-Terminal antibody is used to tag collagen type I for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA, immunoblotting, and immunoprecipitation. It is used as a probe to determine the presence and roles of collagen type I as a cell substrate.

Acciones bioquímicas o fisiológicas

Collagen I interacts with cytoskeleton and regulates cell motility. Mutations in this gene is linked to osteoporotic fracture, osteogenesis imperfecta and recessive classical type Ehlers-Danlos syndrome. It is also associated with idiopathic osteoporosis and atypical Marfan syndrome.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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COL1A2 is a Novel Biomarker to Improve Clinical Prediction in Human Gastric Cancer: Integrating Bioinformatics and Meta-Analysis
Rong L, et al.
Pathology Oncology Research, 24(1), 129-134 (2018)
Fine mapping of the autosomal dominant split hand/split foot locus on chromosome 7, band q21. 3-q22. 1
Scherer SW, et al.
American Journal of Human Genetics, 55(1), 12-12 (1994)
Lina Wang et al.
Molecular medicine reports, 16(1), 310-316 (2017-05-13)
Emerging evidence has demonstrated that endoplasmic reticulum stress (ER) is involved in the pathogenesis of idiopathic pulmonary fibrosis, however, the underlying mechanism remains unclear. Viral infection often triggers a hyperinflammatory response by an expansion of the ER. The present study
Nastaran Tarban et al.
Cells, 11(8) (2022-04-24)
Skeletal muscle repair is initiated by local inflammation and involves the engulfment of dead cells (efferocytosis) by infiltrating macrophages at the injury site. Macrophages orchestrate the whole repair program, and efferocytosis is a key event not only for cell clearance
Joana C Antunes et al.
Tissue engineering. Part A, 21(11-12), 1869-1885 (2015-03-12)
Cartilage damage and/or aging effects can cause constant pain, which limits the patient's quality of life. Although different strategies have been proposed to enhance the limited regenerative capacity of cartilage tissue, the full production of native and functional cartilaginous extracellular

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