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Merck
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Key Documents

SAB2701989

Sigma-Aldrich

Anti-NFE2L2 antibody produced in rabbit

Sinónimos:

NRF2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

liquid

mol wt

68 kDa

species reactivity

human, avian, alligator, rat, plant, mouse

concentration

1 mg/mL

technique(s)

ChIP: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot: 500-3000

UniProt accession no.

Q16236

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NFE2L2(4780)

General description

The nuclear factor erythroid 2-related factor 2 (NFE2L2) is a major transcriptional factor. NRF2 gene codes for NFE2L2. It is a member of the cap ‘n′ collar (Cnc) family of basic leucine zipper transcription factors. It is located on human chromosome 2q31.

Immunogen

Recombinant fragment corresponding to a region within amino acids 108 and 413 of NRF2 (Uniprot ID#Q16236)

Application

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, IP: 1:100-1:500, WB: 1:500-1:3000, ChIP assay: Assay-dependent dilution. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem/physiol Actions

NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995 [PubMed 7868116]).[supplied by OMIM]
The nuclear factor erythroid 2-related factor 2 (Nrf2) controls phase II detoxifying enzymes, antioxidants and efflux transporters like P-glycoprotein (P-gp). De novo mutations in NFE2L2 results in a multisystem disorder. It modulates the expression of more than 200 genes.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Referencia del producto
Descripción
Precios

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H412

Hazard Classifications

Aquatic Chronic 3 - Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Genetic association study of systemic lupus erythematosus and disease subphenotypes in European populations.
Ruiz-Larra?aga O, et al.
Clinical Rheumatology, 35(5), 1161-1168 (2016)
An Xu et al.
Cancer letters, 442, 40-52 (2018-11-08)
Aberrant activation of the RAS cascade ubiquitously occurs in human hepatocellular carcinomas (HCC), regardless of rare mutations of RAS. However, the association between the Ras cascade and hepatic steatosis during hepatocarcinogenesis remains under-investigated. Here, the variation in the constitutive activity
Farhad Jeddi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 97, 286-292 (2017-11-02)
The efficacy of chemotherapeutic agents remains very poor in gastric cancer (GC) patients due to the development of multidrug resistance (MDR) phenotype. The nuclear factor erythroid 2-related factor 2 (Nrf2), is a pivotal transcriptional factor that regulates phase II detoxifying
Peter Huppke et al.
Nature communications, 8(1), 818-818 (2017-10-12)
Transcription factor NRF2, encoded by NFE2L2, is the master regulator of defense against stress in mammalian cells. Somatic mutations of NFE2L2 leading to NRF2 accumulation promote cell survival and drug resistance in cancer cells. Here we show that the same
Aicun Tang et al.
Inflammation, 37(4), 1006-1014 (2014-01-23)
Recently, an increasing number of studies suggest that oxidative stress and inflammation are associated with hepatocellular injuries. Thus, we aimed to evaluate the potential hepatoprotective role of tadehaginoside (TA) on liver lesions induced by carbon tetrachloride (CCl4). The results in
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