S9564
Amyloid Precursor Protein α, Secreted human
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
Sinónimos:
sAPPα
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About This Item
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General description
The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3. It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase.
Application
Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.
Physical form
Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.
Preparation Note
Expressed as a soluble protein and purified under non-denaturing conditions.
Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Neuroscience Research, 63, 410-410 (2001)
In vivo BACE1 inhibition leads to brain A?
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
American Society for Engineering Education (2018)
Dementia: New Insights for the Healthcare Professional, 478-478 (2013)
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsa
Frontiers in Molecular Neuroscience (2017)
Soluble ?-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth
PLoS ONE (2013)
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