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S7951

Sigma-Aldrich

Ovalbumin (257-264) chicken

≥97% (HPLC), lyophilized powder, antigenic peptide 

Sinónimos:

L-seryl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-phenylalanyl-L-a-glutamyl-L-lysyl- L-Leucine trifluoroacetate, OVA (257 - 264), SIINFEKL trifluoroacetate salt, Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu trifluoroaceate, pOV8

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About This Item

Fórmula empírica (notación de Hill):
C45H74N10O13 · xC2HF3O2
Número de CAS:
138831-86-4
Peso molecular:
963.13 (free base basis)
MDL number:
MFCD18452854
UNSPSC Code:
12352200
PubChem Substance ID:
329824593
NACRES:
NA.77

product name

Ovalbumin (257-264) chicken, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

lyophilized powder

color

white to off-white

solubility

H2O: >1 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C45H74N10O13.C2HF3O2/c1-7-25(5)36(55-44(66)37(26(6)8-2)54-38(60)28(47)23-56)43(65)52-32(22-34(48)57)42(64)51-31(21-27-14-10-9-11-15-27)41(63)50-30(17-18-35(58)59)40(62)49-29(16-12-13-19-46)39(61)53-33(45(67)68)20-24(3)4;3-2(4,5)1(6)7/h9-11,14-15,24-26,28-33,36-37,56H,7-8,12-13,16-23,46-47H2,1-6H3,(H2,48,57)(H,49,62)(H,50,63)(H,51,64)(H,52,65)(H,53,61)(H,54,60)(H,55,66)(H,58,59)(H,67,68);(H,6,7)/t25-,26-,28-,29-,30-,31-,32-,33-,36-,37-;/m0./s1

InChI key

BRUCWCULSHVYBQ-VPZPQSBKSA-N

Amino Acid Sequence

Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu

Application

Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies.
Ovalbumin (257-264) chicken has been used:
  • to sensitize mice to generate an asthmatic model
  • in the stimulation of splenocytes
  • for treating dendritic cells to be used as a positive control in cross-presentation studies

Biochem/physiol Actions

Ovalbumin (257-264) chicken is an antigenic peptide and triggers immune response. Administration of the ovalbumin peptide in pregnant mice helps in surpassing ear development anomalies.
SIINFEKL is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA); the ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Primary in vivo responses to ovalbumin. Probing the predictive value of the Kb binding motif.
Lipford GB, et al.
Journal of Immunology, 150(4), 1212-1222 (1993)
Dead Tumor Cells Expressing Infectious Salmon Anemia Virus Fusogenic Protein Favor Antigen Cross-Priming In Vitro
Morales J, et al.
Frontiers in immunology, 8, 1170-1170 (2017)
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer
Burr ML, et al.
Cancer Cell, 36(4), 385-401 (2019)
Murine In vitro Memory T Cell Differentiation
Kim MV et al.
Bio-protocol, 4, 1-4 (2014)
Soluble peptide treatment reverses CD8 T-cell-induced disease in a mouse model of spontaneous tissue-selective autoimmunity
Paek SY, et al.
The Journal of Investigative Dermatology, 132(3), 677-686 (2012)
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