R5903

Anti-Rab11 antibody produced in rabbit

1 mg/mL, affinity isolated antibody, buffered aqueous solution

• MDL number: MFCD01322583
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, mouse, human
• concentration: 1 mg/mL
• technique(s): western blot: 6.6 μg/mL using HeLa cell extract
• UniProt accession no.: P62491
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... RAB11A(8766) ; mouse ... Rab11a(53869) ; rat ... Rab11a(81830)

Descripción

General description

Rab11 (Ras-related protein) has three subtypes -Rab11a, Rab11b, and Rab25. Rab11a (Ras-related protein Rab-11A) belongs to the ras-like small GTP-binding protein superfamily. It is found in nonpolarized cells like fibroblasts and erythroleukemia cells. It is located on human chromosome 15q21.3-q22.31 and on mouse chromosome 9. Rab11a is expressed abundantly.

Immunogen

synthetic peptide corresponding to amino acid residues 1-17 from human Rab11. This sequence is completely conserved in human, mouse, and rat and 94% conserved in C. elegans and amphibians.

Application

Anti-Rab11 has been used in western blotting and immunohistochemistry.

Biochem/physiol Actions

Rab11a (Ras-related protein Rab-11A) participates in the modulation of basolateral to apical transcytosis. It controls TRPV5/6 (Ca2+-selective members) channel trafficking. It is essential for the production of bile canalicular in WIF-B9 cells (rat hepatoma/human fibroblast hybrid cells).

Physical form

Solution in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable