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Q2876

Sigma-Aldrich

Quinacrine mustard dihydrochloride

≥85% (HPLC)

Sinónimos:

2-Methoxy-6-chloro-9-(4-bis[β-chloroethyl]amino-1-methylbutylamino)acridine dihydrochloride, 9-[4-(Bis(2-chloroethyl)amino)-1-methylbutylamino]-6-chloro-2-methoxyacridine dihydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C23H28Cl3N3O · 2HCl
Número de CAS:
4213-45-0
Peso molecular:
541.77
Beilstein/REAXYS Number:
3819822
EC Number:
224-140-9
MDL number:
MFCD00043254
UNSPSC Code:
12352101
PubChem Substance ID:
24899329
NACRES:
NA.32

Quality Level

200

assay

≥85% (HPLC)

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1

InChI

1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H

InChI key

JETDZFFCRPFPDH-UHFFFAOYSA-N

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General description

Quinacrine mustard dihydrochloride is a fluorescent acridine dye, also abbreviated as QM. In an aqueous solution, the chloroethyl groups rapidly lose chloride ions yielding aziridinium cations. These readily react with the carboxyl, thiol, and heterocyclic ring nitrogen groups of proteins and nucleic acids, or with other nucleophiles.

Application

Quinacrine mustard dihydrochloride is used to stain metaphase chromosomes. Recent applications include the Q-banding of maize and karyotyping of fish. The dye is also used as a vital stain for trypanosomes.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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K Tanaka et al.
Biomedical chromatography : BMC, 3(6), 246-250 (1989-11-01)
A simple and precise method was developed for the separation of nucleosides including modified nucleosides and oligonucleotides. Nineteen kinds of nucleosides were completely separated by HPLC using an ODS column (TSK-gel ODS 80TM) and aqueous mobile phases. The RNA molecule
Analysis of human metaphase chromosome set by aid of DNA-binding fluorescent agents.
T Caspersson et al.
Experimental cell research, 253(2), 302-304 (1999-12-10)
Diagnosis of triploidy in metaphases from uncultured amniocytes.
Vanna Pecile et al.
Prenatal diagnosis, 22(1), 78-79 (2002-01-26)
Yong Yu et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(7), 3907-3912 (2003-03-20)
Noncompetitive inhibitors of the nicotinic acetylcholine (ACh) receptors suppress cation flux directly by binding in and blocking the open channel or indirectly by stabilizing closed states of the receptor. The lidocaine derivative QX-314 and the acridine derivative quinacrine act directly
D Fukushi et al.
Cytogenetics and cell genetics, 92(3-4), 254-263 (2001-07-04)
The DNA of Apodemus argenteus was digested with DraI, and the resultant DraI fragment of highly repetitive DNA was isolated and analyzed by DNA filter hybridization, cloning, sequencing, and fluorescence in situ hybridization (FISH). Southern blot hybridization and nucleotide sequencing
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