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Key Documents

PRS2227

Sigma-Aldrich

Anti-DEDAF antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-RING1 and YY1 binding protein

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About This Item

MDL number:
MFCD03791670
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 32 kDa

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q8N488

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RYBP(23429)

Categorías relacionadas

Immunogen

a synthetic peptide corresponding to amino acids 215-228 of human DEDAF The sequence is identical to mouse origin.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2227.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Referencia del producto
Descripción
Precios

SBP2227

DEDAF Blocking Peptide for PRS2227

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Eva J Schaefer et al.
Blood cancer discovery, 3(2), 116-135 (2022-01-12)
Polycomb repressive epigenetic complexes are recurrently dysregulated in cancer. Unlike polycomb repressive complex 2 (PRC2), the role of PRC1 in oncogenesis and therapy resistance is not well-defined. Here, we demonstrate that highly recurrent mutations of the PRC1 subunits BCOR and
Wen Zhao et al.
Biochemical and biophysical research communications, 509(3), 810-816 (2019-01-15)
ETS1 (E26 transformation specific-1) is the founding member of ETS transcriptional factor family. It transcriptionally modulates numerous gene expressions, and is involved in cellular differentiation, tissue remodeling, angiogenesis, drug resistance and tumorigenesis. ETS1 is usually regarded as an oncogene. However
Hagar F Moussa et al.
Nature communications, 10(1), 1931-1931 (2019-05-01)
Polycomb group (PcG) proteins play critical roles in the epigenetic inheritance of cell fate. The Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to enforce gene silencing, but how transcriptional repression is propagated through mitotic cell divisions remains
Bastian Stielow et al.
PLoS genetics, 14(1), e1007193-e1007193 (2018-01-31)
Diverse Polycomb repressive complexes 1 (PRC1) play essential roles in gene regulation, differentiation and development. Six major groups of PRC1 complexes that differ in their subunit composition have been identified in mammals. How the different PRC1 complexes are recruited to
Eric Conway et al.
Molecular cell, 81(17), 3526-3541 (2021-06-30)
BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for maintaining transcriptional repression. However, the precise relationship between BAP1 and
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