P9389

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt

double stranded, alternating copolymer

• Sinónimos: Poly(dG-dC) • Poly(dG-dC)
• Número de CAS: 90385-88-9
• Número MDL: MFCD00131968
• Código UNSPSC: 41106305
• NACRES: NA.51

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Formulario: powder or solid
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.

Aplicación

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:

• in electrophoretic mobility shift assay of transcription factor IIIB complex
• as synthetic copolymers for circular dichroism (CD) spectroscopy studies
• as a positive control in liquid scintillation counting

Otras notas

Alternating copolymer; self-complementary, form double-stranded complex

Definición de unidad

One unit will yield an A₂₆₀ of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)