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Key Documents

P4005

Sigma-Aldrich

Protamine

solid

Sinónimos:

Protamine

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About This Item

Número de CAS:
EC Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Protamine from salmon, Grade IV, Histone, free(Millon test)

biological source

fish (salmon)

Quality Level

type

Grade IV

form

solid

impurities

Histone, free (Millon test)

solubility

H2O: soluble, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

General description

Protamines are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine. It is found to be localized to the sperm head.

Application

Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin. It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.

Biochem/physiol Actions

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamines are found to displace histones in DNA during spermatogenesis in animals and plants. Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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