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Merck
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Key Documents

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P2533

Sigma-Aldrich

Poly-L-ornithine hydrochloride

suitable for ligand binding assays, Mol wt 15,000-30,000

Sinónimos:

L-Ornithine homopolymer hydrochloride

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About This Item

Número de CAS:
26982-21-8
MDL number:
MFCD00166412
UNSPSC Code:
12352209
PubChem Substance ID:
24898334
NACRES:
NA.26

product name

Poly-L-ornithine hydrochloride, mol wt 15,000-30,000

form

powder or solid

Quality Level

200

mol wt

15,000-30,000

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.NCCCC(N)C(O)=O

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Application

Poly-L-ornithine hydrochloride has been used as a substrate analog of acetyl-poly-L-lysine to study substrate binding and catalysis of the NAD-dependent protein deacetylase Hst2. It has been used to bind alginate-polycation-alginate (APA) microcapsules.

Biochem/physiol Actions

Poly-L-ornithine is a polycationic synthetic amino acid polymer. It boosts nasal absorption of hydrophilic macromolecular drugs. Poly-L-ornithine is a specialized coating that acts as a charge modifier.

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kun Luo et al.
Journal of integrative neuroscience, 20(3), 529-539 (2021-10-15)
Rab3a, a subtype protein in the Rab3 family amongst the small G proteins, is closely associated with the learning and memory formation process. Various neuronal stimuli can induce the expression of Rab3a; however, how DNA modification is involved in regulating
Hierarchical Structure Formation of Cylindrical Brush Polymer?Surfactant Complexes
Cong, Y. et al.
Langmuir, 25, 6392-6397 (2005)
Use of Substrate Analogs and Mutagenesis to Study Substrate Binding and Catalysis in the Sir2 Family of NAD-dependent Protein Deacetylases*
Ahlia N
The Journal of Biological Chemistry (2006)
Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer
Yusuke K
Biologicals : Journal of the International Association of Biological Standardization (2017)
Emmanuel C. Opara
Methods in Molecular Biology (2017)
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Artículos

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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