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P2371

Sigma-Aldrich

Pamidronate disodium salt hydrate

≥95% (NMR), solid

Sinónimos:

3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate

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About This Item

Fórmula empírica (notación de Hill):
C3H9NO7P2Na2 · xH2O
Número de CAS:
57248-88-1
Peso molecular:
279.03 (anhydrous basis)
EC Number:
260-647-1
MDL number:
MFCD11045314
UNSPSC Code:
12352200
PubChem Substance ID:
24724574
NACRES:
NA.77
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Quality Level

100

assay

≥95% (NMR)

form

solid

color

white

mp

300 °C

solubility

H2O: 28 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

InChI key

TVQNUQCYOOJTMK-UHFFFAOYSA-L

Biochem/physiol Actions

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).
Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs).[1] It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.[2]

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000082881
0000082881
070M4707V
0000143801
0000143801

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Evangelos Terpos et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(18), 2347-2357 (2013-05-22)
The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) -related bone disease. An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published
George Bullock et al.
Materials (Basel, Switzerland), 13(9) (2020-05-07)
Medication-related osteonecrosis of the jaw (MRONJ) is a side effect of bisphosphonate therapy, characterised by exposed necrotic bone. The soft tissues of the oral mucosa no longer provide a protective barrier and MRONJ patients experience pain, infections and difficulties eating.
Raimund Hirschberg
Current opinion in supportive and palliative care, 6(3), 342-347 (2012-06-20)
More than 10 years ago evidence emerged that bisphosphonate therapy especially in malignant bone diseases is associated with renal complications. The nature of renal injury from bisphosphonates has become clearer in recent years. Pamidronate can rarely cause (collapsing) focal segmental
Yan Wang et al.
PloS one, 7(9), e44868-e44868 (2012-10-03)
It is unclear whether the new anti-catabolic agent denosumab represents a viable alternative to the widely used anti-catabolic agent pamidronate in the treatment of Multiple Myeloma (MM)-induced bone disease. This lack of clarity primarily stems from the lack of sufficient
Amber L Watters et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 115(2), 192-200 (2012-10-06)
We report long-term follow-up of patients with intravenous bisphosphonate-related osteonecrosis of the jaw (BRONJ). Medical and dental histories, including type and duration of bisphosphonate treatment and comorbidities, were analyzed and compared with clinical course of 109 patients with BRONJ at
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