The unit definition for Nystatin is based on the USP reference standard, and its potency is assessed using the USP Nystatin standard. The initial material, nystatin, possesses a unit activity ranging from 4500 to 5000 units/mg. The preparation in question has an approximate potency of 10,000 units/mL, suggesting that the concentration is likely to be around 2 mg/mL. It should be noted that this is a suspension of nystatin in Dulbecco's Phosphate Buffered Saline (DPBS), not merely in water.
N1638
Nystatin Suspension
suspension, non-animal origin, suitable for cell culture, BioReagent
Sinónimos:
Fungicidin, Mycostatin
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Nombre del producto
Nystatin Suspension, suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture
Línea del producto
BioReagent
Nivel de calidad
Formulario
suspension
concentración
10,000 unit/mL in DPBS
técnicas
cell culture | mammalian: suitable
impurezas
endotoxin, tested
color
yellow
espectro de actividad antibiótica
fungi
yeast
Modo de acción
cell membrane | interferes
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
cadena SMILES
C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O
InChI
1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
Clave InChI
VQOXZBDYSJBXMA-QEKUPDCNSA-N
Descripción general
Chemical structure: polyene
Aplicación
Nystatin suspension has been used:
- to inhibit caveolin-mediated endocytosis[1]
- as a component of Eagle′s minimum essential medium (EMEM)[2]
- to enumerate lactic acid bacteria (LAB)[3]
- in preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in toll-like receptor 2 (TLR2)-expressing THP1 cells.
Acciones bioquímicas o fisiológicas
Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.[4]
Precaución
This product is stable at 37°C for three days.
Nota de preparación
It is 0.1μ filtered and cell culture tested.
Otras notas
Nystatin suspension available in 20 mL and 100 mL pack size.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Prevent fungal, yeast, and mold contamination in cell cultures. Discover the best antifungal agent for your cultures with the extensive Sigma® antifungal collection.
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Product N1638 , Nystatin Suspension consists of 10,000 units/mL Nystatin in Dulbecco′s Phosphate Buffered Saline. What does "unit" stand for? If I want 50 mg of this product how much equivalent volume will it be?
1 answer-
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