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N129

Sigma-Aldrich

Naloxone methiodide

≥98% (HPLC), solid

Sinónimos:

(5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide, N-Methylnaloxonium iodide

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About This Item

Fórmula empírica (notación de Hill):
C20H24INO4
Número de CAS:
93302-47-7
Peso molecular:
469.31
MDL number:
MFCD00078592
UNSPSC Code:
12352200
PubChem Substance ID:
24897480
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to tan

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34

InChI

1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1

InChI key

ICONPJDAXITIPI-UXYWFNEESA-N

Application

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.

Biochem/physiol Actions

Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.
Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Piotr Wojciechowski et al.
European journal of pharmacology, 885, 173514-173514 (2020-08-30)
PK20M (Dmt-D-Lys-Phe-Phe-OH) is a novel modified endomorphin-2 (EM-2) peptide producing strong dose- and time-dependent antinociceptive activity. Yet its prototype, endogenous EM-2, has been reported to trigger respiratory and vascular effects such as apnea and hypotension. The purpose of this study
Helvira Melo et al.
Scientific reports, 8(1), 15551-15551 (2018-10-21)
Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of the opioid-induced itch is mediated
Delta opioid receptors are essential to the antiallodynic action of Β2-mimetics in a model of neuropathic pain.
Mélanie Kremer et al.
Molecular pain, 16, 1744806920912931-1744806920912931 (2020-03-27)
Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates
Lewanowitsch Tanya and Irvine RJ
Brain Research, 964(2), 302 -3305 (2003)
Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal
Lewanowitsch Tanya and Irvine RJ
European Journal of Pharmacology, 445(1-2), 61 -667 (2002)
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