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MSAB001

Sigma-Aldrich

SILu™Rich Anti-IL6 MAb, biotin conjugated

clone IL6-4G1, purified from hybridoma cell culture

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

Quality Level

200

conjugate

biotin conjugate

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

IL6-4G1, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoblotting: suitable
immunoprecipitation (IP): 1-2 μg/test using concentrated supernatant of human osteosarcoma MG-63 cells induced with IL 1β

isotype

IgG1

UniProt accession no.

P05231

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... IL6(3569)

Immunogen

Recombinant IL6

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4 containing 15 mM sodium azide

Legal Information

SILu is a trademark of Sigma-Aldrich Co. LLC

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Regine M Schoenherr et al.
Proteomics, 16(15-16), 2141-2145 (2016-04-21)
Immunoaffinity enrichment of peptides coupled to multiple reaction monitoring-mass spectrometry (immuno-MRM) enables highly specific, sensitive, and precise quantification of peptides and post-translational modifications. Major obstacles to developing a large number of immuno-MRM assays are poor availability of monoclonal antibodies (mAbs)
Ailan Guo et al.
Molecular & cellular proteomics : MCP, 13(1), 372-387 (2013-10-17)
Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to regulate RNA processing, gene transcription, DNA damage repair, protein translocation, and signal transduction. Lysine methylation is best known to
Tove Boström et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1021, 3-13 (2015-11-14)
For protein analysis of biological samples, two major strategies are used today; mass spectrometry (MS) and antibody-based methods. Each strategy offers advantages and drawbacks. However, combining the two using an immunoenrichment step with MS analysis brings together the benefits of
L M Biasucci et al.
Circulation, 99(16), 2079-2084 (1999-04-27)
A growing body of evidence suggests a role for inflammation in acute coronary syndromes. The aim of this study was to assess the role of proinflammatory cytokines, their time course, and their association with prognosis in unstable angina. We studied
H C van Zaanen et al.
The Journal of clinical investigation, 98(6), 1441-1448 (1996-09-15)
In vitro as well as in vivo observations have shown that IL6 plays a key role in the pathogenesis of multiple myeloma. Therefore we started a phase I/II dose escalating study with chimeric monoclonal anti-IL6 antibodies (cMab) in multiple myeloma
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